DNM1L (dynamin 1 like)

2008-12-01  

Identity

HGNC
LOCATION
12p11.21
LOCUSID
ALIAS
DLP1,DRP1,DVLP,DYMPLE,EMPF,EMPF1,HDYNIV,OPA5
FUSION GENES

Other Information

Locus ID:

NCBI: 10059
MIM: 603850
HGNC: 2973
Ensembl: ENSG00000087470

Variants:

dbSNP: 10059
ClinVar: 10059
TCGA: ENSG00000087470
COSMIC: DNM1L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087470ENST00000266481O00429
ENSG00000087470ENST00000358214O00429
ENSG00000087470ENST00000381000O00429
ENSG00000087470ENST00000413295B4DDQ3
ENSG00000087470ENST00000414834O00429
ENSG00000087470ENST00000434676B4DPZ9
ENSG00000087470ENST00000452533O00429
ENSG00000087470ENST00000546649F8VYL3
ENSG00000087470ENST00000546757H0YHY4
ENSG00000087470ENST00000547078H0YI79
ENSG00000087470ENST00000547312O00429
ENSG00000087470ENST00000548750F8VZ52
ENSG00000087470ENST00000549701O00429
ENSG00000087470ENST00000550154F8W1W3
ENSG00000087470ENST00000551476F8VUJ9
ENSG00000087470ENST00000551643F8VR28
ENSG00000087470ENST00000553257O00429

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Programmed Cell DeathREACTOMER-HSA-5357801
ApoptosisREACTOMER-HSA-109581
Apoptotic execution phaseREACTOMER-HSA-75153

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
115146142001Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells.608
173010552007Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.391
188386872008Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria.368
193425912009S-nitrosylation of Drp1 mediates beta-amyloid-related mitochondrial fission and neuronal injury.365
177214372007Reversible phosphorylation of Drp1 by cyclic AMP-dependent protein kinase and calcineurin regulates mitochondrial fission and cell death.354
153562672004Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis.334
128610262003The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1.277
175538082007Cyclic AMP-dependent protein kinase phosphorylation of Drp1 regulates its GTPase activity and mitochondrial morphology.264
214597732011Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage.204
208500112010Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization.187

Citation

Dessen P

DNM1L (dynamin 1 like)

Atlas Genet Cytogenet Oncol Haematol. 2008-12-01

Online version: http://atlasgeneticsoncology.org/gene/50558/dnm1l