NEU4 (neuraminidase 4)

2009-03-01 Affiliation

Identity

HGNC

NEU4

LOCATION

2q37.3

LOCUSID

129807

ALIAS

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 129807
MIM: 608527
HGNC: 21328
Ensembl: ENSG00000204099

Variants:

dbSNP: 129807
ClinVar: 129807
TCGA: ENSG00000204099
COSMIC: NEU4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000204099	ENST00000325935	Q8WWR8
ENSG00000204099	ENST00000391969	Q8WWR8
ENSG00000204099	ENST00000391969	B3KR54
ENSG00000204099	ENST00000404257	Q8WWR8
ENSG00000204099	ENST00000405370	Q8WWR8
ENSG00000204099	ENST00000405370	B3KR54
ENSG00000204099	ENST00000407683	Q8WWR8
ENSG00000204099	ENST00000407683	B3KR54
ENSG00000204099	ENST00000415936	C9J2R4
ENSG00000204099	ENST00000420288	C9JRN9
ENSG00000204099	ENST00000423583	C9J5X2
ENSG00000204099	ENST00000426032	C9IZG9
ENSG00000204099	ENST00000428592	C9JEA3
ENSG00000204099	ENST00000435855	F8WE58
ENSG00000204099	ENST00000435894	C9J2V4
ENSG00000204099	ENST00000435934	C9J295

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Other glycan degradation	KEGG	ko00511
Sphingolipid metabolism	KEGG	ko00600
Other glycan degradation	KEGG	hsa00511
Sphingolipid metabolism	KEGG	hsa00600
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Asparagine N-linked glycosylation	REACTOME	R-HSA-446203
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein	REACTOME	R-HSA-446193
Synthesis of substrates in N-glycan biosythesis	REACTOME	R-HSA-446219
Sialic acid metabolism	REACTOME	R-HSA-4085001
Metabolism	REACTOME	R-HSA-1430728
Metabolism of lipids and lipoproteins	REACTOME	R-HSA-556833
Sphingolipid metabolism	REACTOME	R-HSA-428157
Glycosphingolipid metabolism	REACTOME	R-HSA-1660662

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
14962670	2004	Molecular cloning and characterization of NEU4, the fourth member of the human sialidase gene family.	27
15213228	2004	Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells.	26
18651674	2008	Human sialidase as a cancer marker.	22
15885103	2005	Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages.	20
22393058	2012	Sialidase NEU4 hydrolyzes polysialic acids of neural cell adhesion molecules and negatively regulates neurite formation by hippocampal neurons.	18
21521691	2011	Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4.	16
19797320	2010	Human sialidase NEU4 long and short are extrinsic proteins bound to outer mitochondrial membrane and the endoplasmic reticulum, respectively.	7
22287118	2012	NEU4L sialidase overexpression promotes β-catenin signaling in neuroblastoma cells, enhancing stem-like malignant cell growth.	6
27344026	2016	Integrin-mediated cell migration is blocked by inhibitors of human neuraminidase.	5
25144716	2014	Sialidase NEU4 is involved in glioblastoma stem cell survival.	3

Citation

Dessen P

NEU4 (neuraminidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2009-03-01

Online version: http://atlasgeneticsoncology.org/gene/50718/neu4-(neuraminidase-4)