KDM5B (lysine demethylase 5B)

2009-04-01 Affiliation

Identity

HGNC

KDM5B

LOCATION

1q32.1

LOCUSID

10765

ALIAS

CT31,JARID1B,MRT65,PLU-1,PLU1,PPP1R98,PUT1,RBBP2H1A,RBP2-H1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10765
MIM: 605393
HGNC: 18039
Ensembl: ENSG00000117139

Variants:

dbSNP: 10765
ClinVar: 10765
TCGA: ENSG00000117139
COSMIC: KDM5B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000117139	ENST00000235790	B3KV94
ENSG00000117139	ENST00000367264	Q9UGL1
ENSG00000117139	ENST00000367265	Q9UGL1
ENSG00000117139	ENST00000602511	R4GN45
ENSG00000117139	ENST00000648056	A0A3B3IS40
ENSG00000117139	ENST00000648338	A0A3B3IT25
ENSG00000117139	ENST00000648354	A0A3B3ITJ3
ENSG00000117139	ENST00000648469	A0A3B3ITJ7
ENSG00000117139	ENST00000648473	A0A3B3ITE7
ENSG00000117139	ENST00000648676	A0A3B3ITN3
ENSG00000117139	ENST00000648738	A0A3B3IT85
ENSG00000117139	ENST00000649089	A0A3B3ITA9
ENSG00000117139	ENST00000649200	A0A3B3ITR1
ENSG00000117139	ENST00000649770	A0A3B3ISE6
ENSG00000117139	ENST00000649929	A0A3B3IT51
ENSG00000117139	ENST00000650368	A0A3B3IS31
ENSG00000117139	ENST00000650417	A0A3B3ISK2
ENSG00000117139	ENST00000650493	A0A3B3ITR3
ENSG00000117139	ENST00000650569	A0A3B3ITA8

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Chromatin organization	REACTOME	R-HSA-4839726
Chromatin modifying enzymes	REACTOME	R-HSA-3247509
HDMs demethylate histones	REACTOME	R-HSA-3214842
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors	REACTOME	R-HSA-8864260
TFAP2 (AP-2) family regulates transcription of cell cycle factors	REACTOME	R-HSA-8866911

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20478252	2010	A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth.	409
17363312	2007	PLU-1 is an H3K4 demethylase involved in transcriptional repression and breast cancer cell proliferation.	185
20832725	2010	PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway.	136
18048344	2007	JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.	127
20226085	2010	Overexpression of the JmjC histone demethylase KDM5B in human carcinogenesis: involvement in the proliferation of cancer cells through the E2F/RB pathway.	80
24937458	2014	JARID1B is a luminal lineage-driving oncogene in breast cancer.	68
24412361	2014	The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers.	62
22615382	2012	H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence.	61
21369698	2011	PLU-1/JARID1B/KDM5B is required for embryonic survival and contributes to cell proliferation in the mammary gland and in ER+ breast cancer cells.	59
17709396	2007	Functional analysis of the transcription repressor PLU-1/JARID1B.	56

Citation

Dessen P

KDM5B (lysine demethylase 5B)

Atlas Genet Cytogenet Oncol Haematol. 2009-04-01

Online version: http://atlasgeneticsoncology.org/gene/50846/kdm5b-(lysine-demethylase-5b)