BRI3 (brain protein I3)

2009-05-01  

Identity

HGNC
BRI3
LOCATION
7q21.3
LOCUSID
25798
ALIAS
I3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25798
MIM: 615628
HGNC: 1109
Ensembl: ENSG00000164713

Variants:

dbSNP: 25798
ClinVar: 25798
TCGA: ENSG00000164713
COSMIC: BRI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164713ENST00000297290O95415
ENSG00000164713ENST00000491463I3L1V6
ENSG00000164713ENST00000539286F5GXW6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
321605512020NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.13
321605512020NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation.13
205380552010Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.12
205380552010Analysis of the Wnt/B-catenin/TCF4 pathway using SAGE, genome-wide microarray and promoter analysis: Identification of BRI3 and HSF2 as novel targets.12
193666922009BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.0
193666922009BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2.0
184526482008BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.0
184526482008BRI3 associates with SCG10 and attenuates NGF-induced neurite outgrowth in PC12 cells.0
173900492007A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients.27
173900492007A gene signature of 8 genes could identify the risk of recurrence and progression in Dukes' B colon cancer patients.27
165080922005Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain.1
165080922005Crystallization and preliminary X-ray analysis of the GST-fused human Bri3 N-terminal domain.1

Citation

Dessen P

BRI3 (brain protein I3)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50886/tumors-explorer/css/template-nav.css