CMTM8 (CKLF like MARVEL transmembrane domain containing 8)

2009-05-01  

Identity

HGNC
CMTM8
LOCATION
3p22.3
LOCUSID
152189
ALIAS
CKLFSF8,CKLFSF8-V2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 152189
MIM: 607891
HGNC: 19179
Ensembl: ENSG00000170293

Variants:

dbSNP: 152189
ClinVar: 152189
TCGA: ENSG00000170293
COSMIC: CMTM8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170293ENST00000307526Q8IZV2
ENSG00000170293ENST00000458535Q8IZV2

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447197Attention Deficit Disorder with HyperactivityDiseaseClinicalAnnotationassociatedPD29382897
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD29382897

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
127821302003Identification of eight genes encoding chemokine-like factor superfamily members 1-8 (CKLFSF1-8) by in silico cloning and experimental validation.31
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.29
223378762012Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling.19
162631202005Regulation of EGF receptor signaling by the MARVEL domain-containing protein CKLFSF8.12
255515572014Focal chromosomal copy number aberrations identify CMTM8 and GPR177 as new candidate driver genes in osteosarcoma.10
171497032007CMTM8 induces caspase-dependent and -independent apoptosis through a mitochondria-mediated pathway.7
176818412007An alternative splice form of CMTM8 induces apoptosis.6
265033362015CMTM8 inhibits the carcinogenesis and progression of bladder cancer.3
265746342017CMTM8 is Frequently Downregulated in Multiple Solid Tumors.2

Citation

Dessen P

CMTM8 (CKLF like MARVEL transmembrane domain containing 8)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50887/cmtm8