MIIP (migration and invasion inhibitory protein)

2009-05-01  

Identity

HGNC
MIIP
LOCATION
1p36.22
LOCUSID
60672
ALIAS
IIP45
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 60672
MIM: 608772
HGNC: 25715
Ensembl: ENSG00000116691

Variants:

dbSNP: 60672
ClinVar: 60672
TCGA: ENSG00000116691
COSMIC: MIIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116691ENST00000235332Q5JXC2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
146177742003IIp45, an insulin-like growth factor binding protein 2 (IGFBP-2) binding protein, antagonizes IGFBP-2 stimulation of glioma cell invasion.27
200083222010IIp45 inhibits cell migration through inhibition of HDAC6.17
204189112010Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP.15
158673492005Inactivation of the invasion inhibitory gene IIp45 by alternative splicing in gliomas.10
293438502018MiRNA-646-mediated reciprocal repression between HIF-1α and MIIP contributes to tumorigenesis of pancreatic cancer.10
277605662016MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.8
290385212017PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation.8
201036462010Definition of a functional single nucleotide polymorphism in the cell migration inhibitory gene MIIP that affects the risk of breast cancer.7
197732792009Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity.6
277413562017MIIP haploinsufficiency induces chromosomal instability and promotes tumour progression in colorectal cancer.4

Citation

Dessen P

MIIP (migration and invasion inhibitory protein)

Atlas Genet Cytogenet Oncol Haematol. 2009-05-01

Online version: http://atlasgeneticsoncology.org/gene/50899/miip