SPHK2 (sphingosine kinase 2)

2009-06-01  

Identity

HGNC
SPHK2
LOCATION
19q13.33
LOCUSID
56848
ALIAS
SK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56848
MIM: 607092
HGNC: 18859
Ensembl: ENSG00000063176

Variants:

dbSNP: 56848
ClinVar: 56848
TCGA: ENSG00000063176
COSMIC: SPHK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000063176ENST00000245222Q9NRA0
ENSG00000063176ENST00000245222A0A024QZH5
ENSG00000063176ENST00000340932E9PCV4
ENSG00000063176ENST00000426514E7ET12
ENSG00000063176ENST00000593308M0QZP3
ENSG00000063176ENST00000597434A0A075B7A1
ENSG00000063176ENST00000598088Q9NRA0
ENSG00000063176ENST00000598088A0A024QZH5
ENSG00000063176ENST00000599029M0R344
ENSG00000063176ENST00000599748Q9NRA0
ENSG00000063176ENST00000600537Q9NRA0
ENSG00000063176ENST00000601704M0QXX5
ENSG00000063176ENST00000601712M0R0E9

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Sphingolipid metabolismKEGGko00600
Calcium signaling pathwayKEGGko04020
VEGF signaling pathwayKEGGko04370
Sphingolipid metabolismKEGGhsa00600
Calcium signaling pathwayKEGGhsa04020
VEGF signaling pathwayKEGGhsa04370
Fc gamma R-mediated phagocytosisKEGGko04666
Fc gamma R-mediated phagocytosisKEGGhsa04666
Metabolic pathwaysKEGGhsa01100
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
Sphingosine degradationKEGGhsa_M00100
Sphingosine degradationKEGGM00100
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Sphingolipid metabolismREACTOMER-HSA-428157
Sphingolipid de novo biosynthesisREACTOMER-HSA-1660661
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
Apelin signaling pathwayKEGGhsa04371

References

Pubmed IDYearTitleCitations
378983772024Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation.0
380489702024The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents.1
384878842024YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis.0
378983772024Accumulation of sphingosine kinase 2 protein induces malignant transformation in oral keratinocytes associated with stemness, autophagy, senescence, and proliferation.0
380489702024The accumulation of sphingosine kinase 2 disrupts the DNA damage response and promotes resistance to genotoxic agents.1
384878842024YTHDF1-mediated sphingosine kinase 2 upregulation alleviates bupivacaine-induced neurotoxicity via the PI3K/AKT axis.0
364087242023Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.0
369754442023Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma.2
364087242023Sphingosine kinase 2 regulates insulin receptor trafficking in hepatocytes.0
369754442023Inhibition of Sphingosine Kinase 2 Results in PARK2-Mediated Mitophagy and Induces Apoptosis in Multiple Myeloma.2
350882242022miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2.2
353940452022Upregulated flotillins and sphingosine kinase 2 derail AXL vesicular traffic to promote epithelial-mesenchymal transition.3
358342712022Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury.3
360702942022Enzymatic independent role of sphingosine kinase 2 in regulating the expression of type I interferon during influenza A virus infection.2
350882242022miR-153-3p Attenuates the Development of Gastric Cancer by Suppressing SphK2.2

Citation

Dessen P

SPHK2 (sphingosine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2009-06-01

Online version: http://atlasgeneticsoncology.org/gene/50985/favicon/css/template-nav.css