CKMT1A (creatine kinase, mitochondrial 1A)

2009-08-01  

Identity

HGNC
CKMT1A
LOCATION
15q15.3
LOCUSID
548596
ALIAS
CKMT1,U-MtCK,mia-CK

Other Information

Locus ID:

NCBI: 548596
MIM: 613415
HGNC: 31736
Ensembl: ENSG00000223572

Variants:

dbSNP: 548596
ClinVar: 548596
TCGA: ENSG00000223572
COSMIC: CKMT1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000223572ENST00000411750C9J8F6
ENSG00000223572ENST00000413453P12532
ENSG00000223572ENST00000415044C9JT96
ENSG00000223572ENST00000434505P12532
ENSG00000223572ENST00000457648F8WDP9
ENSG00000223572ENST00000626814F8WCN3

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Creatine pathwayKEGGhsa_M00047
Creatine pathwayKEGGM00047
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Creatine metabolismREACTOMER-HSA-71288
Metabolism of polyaminesREACTOMER-HSA-351202

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386153202024Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression.0
386153202024Context-dependent roles for ubiquitous mitochondrial creatine kinase CKMT1 in breast cancer progression.0
368435522023A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.4
368435522023A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.4
350774622022CKMT1A is a novel potential prognostic biomarker in patients with endometrial cancer.0
357056412022An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.2
379545022022Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.0
350774622022CKMT1A is a novel potential prognostic biomarker in patients with endometrial cancer.0
357056412022An integrative pan-cancer analysis of molecular characteristics and oncogenic role of mitochondrial creatine kinase 1A (CKMT1A) in human tumors.2
379545022022Ckmt1 is Dispensable for Mitochondrial Bioenergetics Within White/Beige Adipose Tissue.0
342103372021Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.5
342103372021Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.5
301743042018Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway.31
301743042018Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway.31
281918872017The creatine kinase pathway is a metabolic vulnerability in EVI1-positive acute myeloid leukemia.55

Citation

Dessen P

CKMT1A (creatine kinase, mitochondrial 1A)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51001/meetings/css/lib/dataTables.bootstrap.min.css