PLA2R1 (phospholipase A2 receptor 1)

2009-08-01  

Identity

HGNC
LOCATION
2q24.2
LOCUSID
ALIAS
CLEC13C,PLA2-R,PLA2G1R,PLA2IR,PLA2R
FUSION GENES

Other Information

Locus ID:

NCBI: 22925
MIM: 604939
HGNC: 9042
Ensembl: ENSG00000153246

Variants:

dbSNP: 22925
ClinVar: 22925
TCGA: ENSG00000153246
COSMIC: PLA2R1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153246ENST00000283243Q13018
ENSG00000153246ENST00000392771Q13018

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
TuberculosisKEGGko05152
TuberculosisKEGGhsa05152
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Acyl chain remodelling of PEREACTOMER-HSA-1482839
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PSREACTOMER-HSA-1482801
Acyl chain remodelling of PIREACTOMER-HSA-1482922
Acyl chain remodelling of PGREACTOMER-HSA-1482925

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
195712792009M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy.459
253943212014Thrombospondin type-1 domain-containing 7A in idiopathic membranous nephropathy.158
213235412011Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.136
246109262014Phospholipase A2 receptor autoantibodies and clinical outcome in patients with primary membranous nephropathy.82
233645222013Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy.81
226738852012Enhanced expression of the M-type phospholipase A2 receptor in glomeruli correlates with serum receptor antibodies in primary membranous nephropathy.60
197306832009The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.59
231967972013Determination of primary versus secondary membranous glomerulopathy utilizing phospholipase A2 receptor staining in renal biopsies.56
238132192013Interaction between PLA2R1 and HLA-DQA1 variants associates with anti-PLA2R antibodies and membranous nephropathy.45
223712472012Pathogenesis of membranous nephropathy: recent advances and future challenges.42

Citation

Dessen P

PLA2R1 (phospholipase A2 receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-08-01

Online version: http://atlasgeneticsoncology.org/gene/51021/pla2r1-(phospholipase-a2-receptor-1)