AGK (acylglycerol kinase)

2009-09-01  

Identity

HGNC
AGK
LOCATION
7q34
LOCUSID
55750
ALIAS
CATC5,CTRCT38,MTDPS10,MULK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55750
MIM: 610345
HGNC: 21869
Ensembl: ENSG00000006530

Variants:

dbSNP: 55750
ClinVar: 55750
TCGA: ENSG00000006530
COSMIC: AGK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000006530ENST00000473247E9PC15
ENSG00000006530ENST00000473884F8WDD1
ENSG00000006530ENST00000492693Q53H12
ENSG00000006530ENST00000494688E9PG39
ENSG00000006530ENST00000629555E9PG39
ENSG00000006530ENST00000647568A0A3B3IS09
ENSG00000006530ENST00000648068Q53H12
ENSG00000006530ENST00000648068A4D1U5
ENSG00000006530ENST00000648395A0A3B3ISY9
ENSG00000006530ENST00000648690A0A3B3ITV0
ENSG00000006530ENST00000649014A0A3B3ITX7
ENSG00000006530ENST00000649286Q53H12
ENSG00000006530ENST00000649286A4D1U5
ENSG00000006530ENST00000649365A0A3B3IRM6
ENSG00000006530ENST00000649790A0A3B3IUC9
ENSG00000006530ENST00000649914A0A3B3ITD0
ENSG00000006530ENST00000650006A0A3B3ISZ0
ENSG00000006530ENST00000650365F8WDD1
ENSG00000006530ENST00000650547Q53H12
ENSG00000006530ENST00000650547A4D1U5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerolipid metabolismKEGGko00561
Glycerolipid metabolismKEGGhsa00561
Metabolic pathwaysKEGGhsa01100
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Oncogenic MAPK signalingREACTOMER-HSA-6802957
Signaling by BRAF and RAF fusionsREACTOMER-HSA-6802952

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373548922023Sengers syndrome and AGK-related disorders - Minireview of phenotypic variability and clinical outcomes in molecularly confirmed cases.1
373548922023Sengers syndrome and AGK-related disorders - Minireview of phenotypic variability and clinical outcomes in molecularly confirmed cases.1
345599782022Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway.3
349697472022Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.1
356350532022Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis.2
359347182022Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39.1
345599782022Downregulation of acylglycerol kinase suppresses high-glucose-induced endothelial-mesenchymal transition in human retinal microvascular endothelial cells through regulating the LPAR1/TGF-β/Notch signaling pathway.3
349697472022Excellent Response to MEK Inhibition in an AGK-BRAF Gene Fusion Driven Carcinoma: Case Report and Literature Review.1
356350532022Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis.2
359347182022Acylglycerol kinase promotes ovarian cancer progression and regulates mitochondria function by interacting with ribosomal protein L39.1
331257092021Defining the architecture of the human TIM22 complex by chemical crosslinking.5
341169272021Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.8
331257092021Defining the architecture of the human TIM22 complex by chemical crosslinking.5
341169272021Acylglycerol kinase promotes paclitaxel resistance in nasopharyngeal carcinoma cells by regulating FOXM1 via the JAK2/STAT3 pathway.8
319002082020Acylglycerol kinase promotes tumour growth and metastasis via activating the PI3K/AKT/GSK3β signalling pathway in renal cell carcinoma.22

Citation

Dessen P

AGK (acylglycerol kinase)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51085/css/cancer-prone-explorer/favicon/favicon-32x32.png