CST5 (cystatin D)

2009-09-01  

Identity

HGNC
LOCATION
20p11.21
LOCUSID
ALIAS
-

Other Information

Locus ID:

NCBI: 1473
MIM: 123858
HGNC: 2477
Ensembl: ENSG00000170367

Variants:

dbSNP: 1473
ClinVar: 1473
TCGA: ENSG00000170367
COSMIC: CST5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170367ENST00000304710P28325

Expression (GTEx)

0
1
2
3
4
5

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164713366Tumor necrosis factor alpha (TNF-alpha) inhibitorsChemicalClinicalAnnotationassociatedPD
PA443434Arthritis, RheumatoidDiseaseClinicalAnnotationassociatedPD

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
196626832009Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells.30
157285812005Crystal structure of human cystatin D, a cysteine peptidase inhibitor with restricted inhibition profile.10
202232872010The effects of 1,25-dihydroxyvitamin D3 on colon cancer cells depend on RhoA-ROCK-p38MAPK-MSK signaling.9
261582942015p53 directly activates cystatin D/CST5 to mediate mesenchymal-epithelial transition: a possible link to tumor suppression by vitamin D3.7
263648522015Cystatin D locates in the nucleus at sites of active transcription and modulates gene and protein expression.7
286944992017Cystatin D (CST5): An ultra-early inflammatory biomarker of traumatic brain injury.7

Citation

Dessen P

CST5 (cystatin D)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51126/cst5-(cystatin-d)