SIK3 (SIK family kinase 3)

2009-09-01  

Identity

HGNC
SIK3
LOCATION
11q23.3
LOCUSID
23387
ALIAS
L19,QSK,SEMDK,SIK-3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23387
MIM: 614776
HGNC: 29165
Ensembl: ENSG00000160584

Variants:

dbSNP: 23387
ClinVar: 23387
TCGA: ENSG00000160584
COSMIC: SIK3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000160584ENST00000375300Q9Y2K2
ENSG00000160584ENST00000413553H7C3X8
ENSG00000160584ENST00000415541H7C038
ENSG00000160584ENST00000445177H0Y4E8
ENSG00000160584ENST00000446921Q9Y2K2
ENSG00000160584ENST00000454905H7C042

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
233931342013The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases.36
248867092014Amerindian-specific regions under positive selection harbour new lipid variants in Latinos.34
295266962018LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia.17
265901482016SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype.16
225881262012cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes.15
29211348201814-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs).13
213996632011Identification of salt-inducible kinase 3 as a novel tumor antigen associated with tumorigenesis of ovarian cancer.12
270099672016Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3.11
286583032017Critical role of SIK3 in mediating high salt and IL-17 synergy leading to breast cancer cell proliferation.11

Citation

Dessen P

SIK3 (SIK family kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-09-01

Online version: http://atlasgeneticsoncology.org/gene/51135/sik3-(sik-family-kinase-3)