SLC2A12 (solute carrier family 2 member 12)

2009-10-01  

Identity

HGNC
SLC2A12
LOCATION
6q23.2
LOCUSID
154091
ALIAS
GLUT12,GLUT8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 154091
MIM: 610372
HGNC: 18067
Ensembl: ENSG00000146411

Variants:

dbSNP: 154091
ClinVar: 154091
TCGA: ENSG00000146411
COSMIC: SLC2A12

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146411ENST00000275230Q8TD20

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Facilitative Na+-independent glucose transportersREACTOMER-HSA-428790

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365940842023Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.1
379400662023Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.2
365940842023Inhibition of androgen receptor enhanced the anticancer effects of everolimus through targeting glucose transporter 12.1
379400662023Hypoxia promotes the growth and metastasis of ovarian cancer cells by suppressing ferroptosis via upregulating SLC2A12.2
347916272021Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.1
347916272021Epithelial mesenchymal transition regulator TWIST1 transcription factor stimulates glucose uptake through upregulation of GLUT1, GLUT3, and GLUT12 in vitro.1
329469642020Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.29
330774972020Alternative Splicing and Cleavage of GLUT8.12
329469642020Let-7a-5p inhibits triple-negative breast tumor growth and metastasis through GLUT12-mediated warburg effect.29
330774972020Alternative Splicing and Cleavage of GLUT8.12
303521232019GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.4
310022002019GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.6
303521232019GLUT12 expression and regulation in murine small intestine and human Caco-2 cells.4
310022002019GLUT12 and adipose tissue: Expression, regulation and its relation with obesity in mice.6
291874482017Potential Roles of GLUT12 for Glucose Sensing and Cellular Migration in MCF-7 Human Breast Cancer Cells Under High Glucose Conditions.8

Citation

Dessen P

SLC2A12 (solute carrier family 2 member 12)

Atlas Genet Cytogenet Oncol Haematol. 2009-10-01

Online version: http://atlasgeneticsoncology.org/gene/51172/img/js/web-card-gene.js