RGN (regucalcin)

2009-11-01  

Identity

HGNC
LOCATION
Xp11.3
LOCUSID
ALIAS
GNL,HEL-S-41,RC,SMP30

Other Information

Locus ID:

NCBI: 9104
MIM: 300212
HGNC: 9989
Ensembl: ENSG00000130988

Variants:

dbSNP: 9104
ClinVar: 9104
TCGA: ENSG00000130988
COSMIC: RGN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130988ENST00000336169Q15493
ENSG00000130988ENST00000336169V9HWF8
ENSG00000130988ENST00000352078Q15493
ENSG00000130988ENST00000352078V9HWF8
ENSG00000130988ENST00000397180Q15493
ENSG00000130988ENST00000397180V9HWF8
ENSG00000130988ENST00000457380Q15493

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Pentose phosphate pathwayKEGGko00030
Ascorbate and aldarate metabolismKEGGko00053
Pentose phosphate pathwayKEGGhsa00030
Ascorbate and aldarate metabolismKEGGhsa00053
Metabolic pathwaysKEGGhsa01100
Carbon metabolismKEGGhsa01200
Carbon metabolismKEGGko01200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
196901762009Beta-catenin regulates vitamin C biosynthesis and cell survival in murine liver.19
159623152005Overexpression of regucalcin suppresses cell proliferation in cloned rat hepatoma H4-II-E cells: involvement of intracellular signaling factors and cell cycle-related genes.15
199467312010Hepatic senescence marker protein-30 is involved in the progression of nonalcoholic fatty liver disease.10
213474212011Senescence marker protein 30 (SMP30) expression in eukaryotic cells: existence of multiple species and membrane localization.10
260723072015Kidney tissue proteomics reveals regucalcin downregulation in response to diabetic nephropathy with reflection in urinary exosomes.10
234530392013Involvement of regucalcin in lipid metabolism and diabetes.9
153581882004Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells.8
193478722009Regucalcin is under-expressed in human breast and prostate cancers: Effect of sex steroid hormones.8
226528982012Role of regucalcin in brain calcium signaling: involvement in aging.8
185078312008Senescence marker protein 30 in acute liver failure: validation of a mass spectrometry proteomics assay.7

Citation

Dessen P

RGN (regucalcin)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51174/rgn