TNIP3 (TNFAIP3 interacting protein 3)

2009-11-01 Affiliation

Identity

HGNC

TNIP3

LOCATION

4q27

LOCUSID

79931

ALIAS

ABIN-3,LIND

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79931
MIM: 608019
HGNC: 19315
Ensembl: ENSG00000050730

Variants:

dbSNP: 79931
ClinVar: 79931
TCGA: ENSG00000050730
COSMIC: TNIP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000050730	ENST00000057513	Q96KP6
ENSG00000050730	ENST00000507879	Q96KP6
ENSG00000050730	ENST00000509841	Q96KP6
ENSG00000050730	ENST00000515036	H0Y9J7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
Deubiquitination	REACTOME	R-HSA-5688426
Ovarian tumor domain proteases	REACTOME	R-HSA-5689896

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
19464428	2009	ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling.	61
19617629	2009	Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10.	53
17088249	2007	LIND/ABIN-3 is a novel lipopolysaccharide-inducible inhibitor of NF-kappaB activation.	21
17485448	2007	ABIN-3: a molecular basis for species divergence in interleukin-10-induced anti-inflammatory actions.	19
20628086	2010	Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.	11
18081698	2008	Expression of the NF-kappaB inhibitor ABIN-3 in response to TNF and toll-like receptor 4 stimulation is itself regulated by NF-kappaB.	10
28005267	2017	Human gingiva transcriptome during wound healing.	6
22093807	2012	A pro-inflammatory role for A20 and ABIN family proteins in human fibroblast-like synoviocytes in rheumatoid arthritis.	5

Citation

Dessen P

TNIP3 (TNFAIP3 interacting protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51200/tnip3