KLF17 (Kruppel like factor 17)

2009-11-01  

Identity

HGNC
KLF17
LOCATION
1p34.1
LOCUSID
128209
ALIAS
ZLF393,ZNF393,Zfp393
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 128209
MIM: 609602
HGNC: 18830
Ensembl: ENSG00000171872

Variants:

dbSNP: 128209
ClinVar: 128209
TCGA: ENSG00000171872
COSMIC: KLF17

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171872ENST00000372299Q5JT82
ENSG00000171872ENST00000476802A0A0U1RR65

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198019742009KLF17 is a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer.83
164609072006Human KLF17 is a new member of the Sp/KLF family of transcription factors.46
242202912014Identification of KLF17 as a novel epithelial to mesenchymal transition inducer via direct activation of TWIST1 in endometrioid endometrial cancer.18
233254442013Down-regulated KLF17 expression is associated with tumor invasion and poor prognosis in hepatocellular carcinoma.15
256524672015Krüppel-like factors in hepatocellular carcinoma.15
245043642014DJ-1 upregulates breast cancer cell invasion by repressing KLF17 expression.14
251118982014Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells.14
257663202015KLF17 empowers TGF-β/Smad signaling by targeting Smad3-dependent pathway to suppress tumor growth and metastasis during cancer progression.14
257064822015Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.12
222400242012Reduced expression of Krüppel-like factor 17 is related to tumor growth and poor prognosis in lung adenocarcinoma.10

Citation

Dessen P

KLF17 (Kruppel like factor 17)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51223/klf17