CDK1 (cyclin dependent kinase 1)

2010-01-01  

Identity

HGNC
CDK1
LOCATION
10q21.2
LOCUSID
983
ALIAS
CDC2,CDC28A,P34CDC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 983
MIM: 116940
HGNC: 1722
Ensembl: ENSG00000170312

Variants:

dbSNP: 983
ClinVar: 983
TCGA: ENSG00000170312
COSMIC: CDK1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170312ENST00000316629P06493
ENSG00000170312ENST00000316629A0A024QZJ8
ENSG00000170312ENST00000373809P06493
ENSG00000170312ENST00000373809A0A024QZJ8
ENSG00000170312ENST00000395284P06493
ENSG00000170312ENST00000448257A0A024QZP7
ENSG00000170312ENST00000519078E5RIU6
ENSG00000170312ENST00000614696A0A087WZZ9

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell cycleKEGGko04110
p53 signaling pathwayKEGGko04115
Gap junctionKEGGko04540
Progesterone-mediated oocyte maturationKEGGko04914
Cell cycleKEGGhsa04110
p53 signaling pathwayKEGGhsa04115
Gap junctionKEGGhsa04540
Progesterone-mediated oocyte maturationKEGGhsa04914
Oocyte meiosisKEGGko04114
Oocyte meiosisKEGGhsa04114
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169
Viral carcinogenesisKEGGhsa05203
Viral carcinogenesisKEGGko05203
Cell cycle - G2/M transitionKEGGhsa_M00693
Cell cycle - G2/M transitionKEGGM00693
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
MAPK family signaling cascadesREACTOMER-HSA-5683057
MAPK1/MAPK3 signalingREACTOMER-HSA-5684996
RAF-independent MAPK1/3 activationREACTOMER-HSA-112409
MAPK3 (ERK1) activationREACTOMER-HSA-110056
MAPK6/MAPK4 signalingREACTOMER-HSA-5687128
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional Regulation by TP53REACTOMER-HSA-3700989
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
G2/M DNA damage checkpointREACTOMER-HSA-69473
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexREACTOMER-HSA-75035
G2/M DNA replication checkpointREACTOMER-HSA-69478
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G0 and Early G1REACTOMER-HSA-1538133
G1/S TransitionREACTOMER-HSA-69206
G1/S-Specific TranscriptionREACTOMER-HSA-69205
E2F mediated regulation of DNA replicationREACTOMER-HSA-113510
E2F-enabled inhibition of pre-replication complex formationREACTOMER-HSA-113507
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Cyclin A/B1 associated events during G2/M transitionREACTOMER-HSA-69273
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesREACTOMER-HSA-170145
Cyclin B2 mediated eventsREACTOMER-HSA-157881
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Recruitment of NuMA to mitotic centrosomesREACTOMER-HSA-380320
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic ProphaseREACTOMER-HSA-68875
Golgi Cisternae Pericentriolar Stack ReorganizationREACTOMER-HSA-162658
Condensation of Prophase ChromosomesREACTOMER-HSA-2299718
MASTL Facilitates Mitotic ProgressionREACTOMER-HSA-2465910
Nuclear Envelope BreakdownREACTOMER-HSA-2980766
Activation of NIMA Kinases NEK9, NEK6, NEK7REACTOMER-HSA-2980767
Nuclear Pore Complex (NPC) DisassemblyREACTOMER-HSA-3301854
Depolymerisation of the Nuclear LaminaREACTOMER-HSA-4419969
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Condensation of Prometaphase ChromosomesREACTOMER-HSA-2514853
Regulation of mitotic cell cycleREACTOMER-HSA-453276
APC/C-mediated degradation of cell cycle proteinsREACTOMER-HSA-174143
Regulation of APC/C activators between G1/S and early anaphaseREACTOMER-HSA-176408
Phosphorylation of Emi1REACTOMER-HSA-176417
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176814
Phosphorylation of the APC/CREACTOMER-HSA-176412
APC/C:Cdc20 mediated degradation of mitotic proteinsREACTOMER-HSA-176409
APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointREACTOMER-HSA-179419
Cdc20:Phospho-APC/C mediated degradation of Cyclin AREACTOMER-HSA-174184
APC/C:Cdc20 mediated degradation of Cyclin BREACTOMER-HSA-174048
The role of GTSE1 in G2/M progression after G2 checkpointREACTOMER-HSA-8852276
AURKA Activation by TPX2REACTOMER-HSA-8854518
TP53 Regulates Transcription of Cell Cycle GenesREACTOMER-HSA-6791312
TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestREACTOMER-HSA-6804114
Regulation of TP53 ActivityREACTOMER-HSA-5633007
Regulation of TP53 Expression and DegradationREACTOMER-HSA-6806003
Regulation of TP53 DegradationREACTOMER-HSA-6804757

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA166122986radiotherapyChemicalClinicalAnnotationassociatedPD25054431
PA166124223pneumonitisDiseaseClinicalAnnotationassociatedPD25054431

References

Pubmed IDYearTitleCitations
381030052024Targeting Cyclin-Dependent Kinase 1 Induces Apoptosis and Cell Cycle Arrest of Activated Hepatic Stellate Cells.0
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
386403222024CDK1 and CCNA2 play important roles in oral squamous cell carcinoma.0
381030052024Targeting Cyclin-Dependent Kinase 1 Induces Apoptosis and Cell Cycle Arrest of Activated Hepatic Stellate Cells.0
384292682024OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway.1
386403222024CDK1 and CCNA2 play important roles in oral squamous cell carcinoma.0
353482682023NCAPD2 promotes breast cancer progression through E2F1 transcriptional regulation of CDK1.8
365725702023ASRGL1 downregulation suppresses hepatocellular carcinoma tumorigenesis in a CDK1-dependent manner.0
366818992023CDK1 bridges NF-κB and β-catenin signaling in response to H. pylori infection in gastric tumorigenesis.7
367820892023Phosphorylation of USP29 by CDK1 Governs TWIST1 Stability and Oncogenic Functions.8
369888912023ELF3 promotes gemcitabine resistance through PKMYT1/CDK1 signaling pathway in gallbladder cancer.2
372169992023BRK confers tamoxifen-resistance in breast cancer via regulation of tyrosine phosphorylation of CDK1.0
373656812023Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.1
374284662023Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer.16
376673822023Deubiquitylase YOD1 regulates CDK1 stability and drives triple-negative breast cancer tumorigenesis.5

Citation

Dessen P

CDK1 (cyclin dependent kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51245/js/css/lib/img/logo-atlas-4.svg