CLEC2A (C-type lectin domain family 2 member A)

2010-01-01  

Identity

HGNC
LOCATION
12p13.31
LOCUSID
ALIAS
INPE5792,KACL,PILAR,UNQ5792
FUSION GENES

Other Information

Locus ID:

NCBI: 387836
MIM: 612087
HGNC: 24191
Ensembl: ENSG00000188393

Variants:

dbSNP: 387836
ClinVar: 387836
TCGA: ENSG00000188393
COSMIC: CLEC2A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188393ENST00000339766Q6UVW9
ENSG00000188393ENST00000455827Q6UVW9

Expression (GTEx)

0
5
10
15
20
25
30

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185508552008PILAR is a novel modulator of human T-cell expansion.18
196307982009Novel interactions in platelet biology: CLEC-2/podoplanin and laminin/GPVI.13
279600392017Physiologic and pathophysiologic roles of interaction between C-type lectin-like receptor 2 and podoplanin: partners from in utero to adulthood.10
201947512010Interaction of C-type lectin-like receptors NKp65 and KACL facilitates dedicated immune recognition of human keratinocytes.0
251502982014CLEC-2 expression is maintained on activated platelets and on platelet microparticles.0
255108542015Key residues at the membrane-distal surface of KACL, but not glycosylation, determine the functional interaction of the keratinocyte-specific C-type lectin-like receptor KACL with its high-affinity receptor NKp65.0
264164202015PDGF upregulates CLEC-2 to induce T regulatory cells.0

Citation

Dessen P

CLEC2A (C-type lectin domain family 2 member A)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51249/clec2a