WDR11 (WD repeat domain 11)

2010-01-01  

Identity

HGNC
LOCATION
10q26.12
LOCUSID
ALIAS
BRWD2,DR11,HH14,SRI1,WDR15
FUSION GENES

Other Information

Locus ID:

NCBI: 55717
MIM: 606417
HGNC: 13831
Ensembl: ENSG00000120008

Variants:

dbSNP: 55717
ClinVar: 55717
TCGA: ENSG00000120008
COSMIC: WDR11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120008ENST00000263461Q9BZH6
ENSG00000120008ENST00000497136S4R3P9
ENSG00000120008ENST00000604585S4R3Z0
ENSG00000120008ENST00000605543S4R451

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
208879642010WDR11, a WD protein that interacts with transcription factor EMX1, is mutated in idiopathic hypogonadotropic hypogonadism and Kallmann syndrome.52
115360512001A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.10
126846852003FGFR2 and WDR11 are neighboring oncogene and tumor suppressor gene on human chromosome 10q26.9
294268652018The WDR11 complex facilitates the tethering of AP-1-derived vesicles.6
292632002018WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome.4
261789832015Cellular Protein WDR11 Interacts with Specific Herpes Simplex Virus Proteins at the trans-Golgi Network To Promote Virus Replication.3
284538582017Digenic Inheritance of PROKR2 and WDR11 Mutations in Pituitary Stalk Interruption Syndrome.3
126846932003Recombination cluster around FGFR2-WDR11-HTPAPL locus on human chromosome 10q26.2

Citation

Dessen P

WDR11 (WD repeat domain 11)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51278/wdr11