MFAP5 (microfibril associated protein 5)

2010-01-01  

Identity

HGNC
MFAP5
LOCATION
12p13.31
LOCUSID
8076
ALIAS
AAT9,MAGP-2,MAGP2,MFAP-5,MP25

Other Information

Locus ID:

NCBI: 8076
MIM: 601103
HGNC: 29673
Ensembl: ENSG00000197614

Variants:

dbSNP: 8076
ClinVar: 8076
TCGA: ENSG00000197614
COSMIC: MFAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197614ENST00000359478Q13361
ENSG00000197614ENST00000396549Q13361
ENSG00000197614ENST00000433590B3KW70
ENSG00000197614ENST00000535336F5H413
ENSG00000197614ENST00000535411H0YG03
ENSG00000197614ENST00000537009F5H2W4
ENSG00000197614ENST00000540087Q13361
ENSG00000197614ENST00000543369F5GYX4
ENSG00000197614ENST00000543467H0YGS3
ENSG00000197614ENST00000544211F5H7Z2
ENSG00000197614ENST00000544889F5H1C0

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Extracellular matrix organizationREACTOMER-HSA-1474244
Elastic fibre formationREACTOMER-HSA-1566948
Molecules associated with elastic fibresREACTOMER-HSA-2129379

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
369347972023Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling.1
371568392023Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix.7
369347972023Microfibril-Associated Glycoprotein-2 Promoted Fracture Healing via Integrin αvβ3/PTK2/AKT Signaling.1
371568392023Targeting MFAP5 in cancer-associated fibroblasts sensitizes pancreatic cancer to PD-L1-based immunochemotherapy via remodeling the matrix.7
349151362022MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.2
349151362022MAGP2 induces tumor progression by enhancing uPAR-mediated cell proliferation.2
328957662021Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.0
328957662021Reduced MFAP5 expression in stroma of gallbladder adenocarcinoma and its potential diagnostic utility.0
311902772020Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling.14
314225032020Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.5
322930742020CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling.18
311902772020Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling.14
314225032020Loss of microfibril-associated protein 5 (MFAP5) expression in colon cancer stroma.5
322930742020CAFs-derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling.18
303206612019Immunohistochemical Expression of Microfibrillar-associated Protein 5 (MFAP5) in Invasive Breast Carcinoma of No Special Type.1

Citation

Dessen P

MFAP5 (microfibril associated protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2010-01-01

Online version: http://atlasgeneticsoncology.org/gene/51289/js/lib/favicon/apple-touch-icon.png