DRAM2 (DNA damage regulated autophagy modulator 2)

DRAM2 (DNA damage regulated autophagy modulator 2)

2010-02-01 Affiliation

Identity

HGNC

LOCATION

1p13.3

LOCUSID

ALIAS

CORD21,PRO180,TMEM77,WWFQ154

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 128338
MIM: 613360
HGNC: 28769
Ensembl: ENSG00000156171

Variants:

dbSNP: 128338
ClinVar: 128338
TCGA: ENSG00000156171
COSMIC: DRAM2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000156171	ENST00000286692	Q6UX65
ENSG00000156171	ENST00000286692	A0A024R0B7
ENSG00000156171	ENST00000496430	S4R2Z2
ENSG00000156171	ENST00000539140	Q6UX65
ENSG00000156171	ENST00000539140	A0A024R0B7

Expression (GTEx)

0

10

20

30

40

50

60

70

80

90

100

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35806404	2022	The Clinical Spectrum and Disease Course of DRAM2 Retinopathy.	3
35806404	2022	The Clinical Spectrum and Disease Course of DRAM2 Retinopathy.	3
32079136	2020	Clinical Course and Electron Microscopic Findings in Lymphocytes of Patients with DRAM2-Associated Retinopathy.	3
32079136	2020	Clinical Course and Electron Microscopic Findings in Lymphocytes of Patients with DRAM2-Associated Retinopathy.	3
31394102	2019	Characterization of the cone-rod dystrophy retinal phenotype caused by novel homozygous DRAM2 mutations.	4
31394102	2019	Characterization of the cone-rod dystrophy retinal phenotype caused by novel homozygous DRAM2 mutations.	4
27764573	2017	MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2.	63
27764573	2017	MIR144* inhibits antimicrobial responses against Mycobacterium tuberculosis in human monocytes and macrophages by targeting the autophagy protein DRAM2.	63
25983245	2015	Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.	23
26509668	2015	Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population.	5
26720460	2015	Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene.	8
25983245	2015	Biallelic mutations in the autophagy regulator DRAM2 cause retinal dystrophy with early macular involvement.	23
26509668	2015	Genetic Variants on Chromosome 1p13.3 Are Associated with Non-ST Elevation Myocardial Infarction and the Expression of DRAM2 in the Finnish Population.	5
26720460	2015	Disease Expression in Autosomal Recessive Retinal Dystrophy Associated With Mutations in the DRAM2 Gene.	8
21584698	2012	The expression of damage-regulated autophagy modulator 2 (DRAM2) contributes to autophagy induction.	29

Citation

Dessen P

DRAM2 (DNA damage regulated autophagy modulator 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51330/js/lib/zoomerang.js