KCNN3 (potassium calcium-activated channel subfamily N member 3)

2010-02-01  

Identity

HGNC
KCNN3
LOCATION
1q21.3
LOCUSID
3782
ALIAS
KCa2.3,SK3,SKCA3,ZLS3,hSK3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3782
MIM: 602983
HGNC: 6292
Ensembl: ENSG00000143603

Variants:

dbSNP: 3782
ClinVar: 3782
TCGA: ENSG00000143603
COSMIC: KCNN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143603ENST00000271915Q9UGI6
ENSG00000143603ENST00000358505Q9UGI6
ENSG00000143603ENST00000361147Q9UGI6
ENSG00000143603ENST00000618040A0A087WYJ0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Insulin secretionKEGGhsa04911
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Ca2+ activated K+ channelsREACTOMER-HSA-1296052

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
365029182023Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function.2
365029182023Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function.2
354883062022The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction.2
354883062022The role of SK3 in progesterone-induced inhibition of human fallopian tubal contraction.2
333100412021HDAC2-dependent remodeling of K(Ca)2.2 (KCNN2) and K(Ca)2.3 (KCNN3) K(+) channels in atrial fibrillation with concomitant heart failure.7
335942612021Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies.16
333100412021HDAC2-dependent remodeling of K(Ca)2.2 (KCNN2) and K(Ca)2.3 (KCNN3) K(+) channels in atrial fibrillation with concomitant heart failure.7
335942612021Syndromic disorders caused by gain-of-function variants in KCNH1, KCNK4, and KCNN3-a subgroup of K(+) channelopathies.16
326407382020Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.12
326407382020Hypoxia Promotes Prostate Cancer Aggressiveness by Upregulating EMT-Activator Zeb1 and SK3 Channel Expression.12
309225692019Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study.6
311552822019Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca(2+)-Activated K(+) Channel SK3 Cause Zimmermann-Laband Syndrome.26
314862522019Liability of the voltage-gated potassium channel KCNN3 repeat polymorphism to acute oxaliplatin-induced peripheral neurotoxicity.5
309225692019Role of SK channel activation in determining the action potential configuration in freshly isolated human atrial myocytes from the SKArF study.6
311552822019Gain-of-Function Mutations in KCNN3 Encoding the Small-Conductance Ca(2+)-Activated K(+) Channel SK3 Cause Zimmermann-Laband Syndrome.26

Citation

Dessen P

KCNN3 (potassium calcium-activated channel subfamily N member 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51331/css/favicon/js/lib/zoomerang.js