NTSR2 (neurotensin receptor 2)

2010-02-01 Affiliation

Identity

HGNC

NTSR2

LOCATION

2p25.1

LOCUSID

23620

ALIAS

NTR2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 23620
MIM: 605538
HGNC: 8040
Ensembl: ENSG00000169006

Variants:

dbSNP: 23620
ClinVar: 23620
TCGA: ENSG00000169006
COSMIC: NTSR2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000169006	ENST00000306928	O95665

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

References

Pubmed ID	Year	Title	Citations
19874574	2009	Genetical genomic determinants of alcohol consumption in rats and humans.	93
15383539	2004	Common structural basis for constitutive activity of the ghrelin receptor family.	67
19086053	2009	Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.	34
20468071	2010	Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.	17
20048080	2010	Altered expression of neurotensin receptors is associated with the differentiation state of prostate cancer.	15
23109725	2012	Differential expression of neurotensin and specific receptors, NTSR1 and NTSR2, in normal and malignant human B lymphocytes.	11
19968961	2010	Intermolecular cross-talk between NTR1 and NTR2 neurotensin receptor promotes intracellular sequestration and functional inhibition of NTR1 receptors.	9
26298774	2015	Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells.	8
30770901	2019	Neurotensin and its receptors mediate neuroendocrine transdifferentiation in prostate cancer.	5
28498396	2017	Diverse expression patterns and tumorigenic role of neurotensin signaling components in colorectal cancer cells.	4

Citation

Dessen P

NTSR2 (neurotensin receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-02-01

Online version: http://atlasgeneticsoncology.org/gene/51345/ntsr2