USP10 (ubiquitin specific peptidase 10)

2010-03-01 Affiliation

Identity

HGNC

USP10

LOCATION

16q24.1

LOCUSID

9100

ALIAS

UBPO

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9100
MIM: 609818
HGNC: 12608
Ensembl: ENSG00000103194

Variants:

dbSNP: 9100
ClinVar: 9100
TCGA: ENSG00000103194
COSMIC: USP10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000103194	ENST00000219473	Q14694
ENSG00000103194	ENST00000540269	Q68D90
ENSG00000103194	ENST00000562283	H3BQC6
ENSG00000103194	ENST00000563048	H3BNL0
ENSG00000103194	ENST00000563386	H3BNP1
ENSG00000103194	ENST00000563892	H3BVF1
ENSG00000103194	ENST00000567526	H3BQP1
ENSG00000103194	ENST00000569038	J3KT19
ENSG00000103194	ENST00000569925	H3BNS8
ENSG00000103194	ENST00000570053	H3BNA1
ENSG00000103194	ENST00000570191	Q14694

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Metabolism of proteins	REACTOME	R-HSA-392499
Post-translational protein modification	REACTOME	R-HSA-597592
DNA Repair	REACTOME	R-HSA-73894
DNA Damage Bypass	REACTOME	R-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template	REACTOME	R-HSA-110313
Termination of translesion DNA synthesis	REACTOME	R-HSA-5656169
Deubiquitination	REACTOME	R-HSA-5688426
Ub-specific processing proteases	REACTOME	R-HSA-5689880

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
21962518	2011	Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13.	250
20096447	2010	USP10 regulates p53 localization and stability by deubiquitinating p53.	174
27022092	2016	G3BP-Caprin1-USP10 complexes mediate stress granule condensation and associate with 40S subunits.	114
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
11439350	2001	Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease.	59
19398555	2009	The deubiquitinating enzyme USP10 regulates the post-endocytic sorting of cystic fibrosis transmembrane conductance regulator in airway epithelial cells.	53
24332849	2013	USP10 antagonizes c-Myc transcriptional activation through SIRT6 stabilization to suppress tumor formation.	46
24270572	2013	USP10 inhibits genotoxic NF-κB activation by MCPIP1-facilitated deubiquitination of NEMO.	34
16368182	2005	The ubiquitin-specific protease USP10 modulates androgen receptor function.	27
26876938	2016	Deubiquitination and Activation of AMPK by USP10.	25

Citation

Dessen P

USP10 (ubiquitin specific peptidase 10)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51378/usp10-(ubiquitin-specific-peptidase-10)