TICRR (TOPBP1 interacting checkpoint and replication regulator)

2010-03-01  

Identity

HGNC
TICRR
LOCATION
15q26.1
LOCUSID
90381
ALIAS
C15orf42,SLD3,Treslin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 90381
MIM: 613298
HGNC: 28704
Ensembl: ENSG00000140534

Variants:

dbSNP: 90381
ClinVar: 90381
TCGA: ENSG00000140534
COSMIC: TICRR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140534ENST00000268138Q7Z2Z1
ENSG00000140534ENST00000560985Q7Z2Z1
ENSG00000140534ENST00000561095H0YN97

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
201160892010Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.96
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
216464022011Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.52
200809542010A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.47
237045732013Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.27
257372832015Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.16
287850142017Ensa controls S-phase length by modulating Treslin levels.13
284390152017Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.11
236966512013Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.10
285213752017A Genetic Marker Associated with Shoulder Dislocation.2

Citation

Dessen P

TICRR (TOPBP1 interacting checkpoint and replication regulator)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/51393/ticrr