LIN28A (lin-28 homolog A)

2010-04-01  

Identity

HGNC
LIN28A
LOCATION
1p36.11
LOCUSID
79727
ALIAS
CSDD1,LIN-28,LIN28,ZCCHC1,lin-28A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 79727
MIM: 611043
HGNC: 15986
Ensembl: ENSG00000131914

Variants:

dbSNP: 79727
ClinVar: 79727
TCGA: ENSG00000131914
COSMIC: LIN28A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000131914ENST00000254231Q9H9Z2
ENSG00000131914ENST00000326279Q9H9Z2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Transcriptional regulation of pluripotent stem cellsREACTOMER-HSA-452723

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
198789812009An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation.594
197033962009TUT4 in concert with Lin28 suppresses microRNA biogenesis through pre-microRNA uridylation.361
194836832009Lin28 promotes transformation and is associated with advanced human malignancies.341
221184632011Lin28A and Lin28B inhibit let-7 microRNA biogenesis by distinct mechanisms.246
185505442008Determinants of microRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28.173
191536032009Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.150
195783602009A role for Lin28 in primordial germ-cell development and germ-cell malignancy.146
201012132010Pluripotency factors Lin28 and Oct4 identify a sub-population of stem cell-like cells in ovarian cancer.120
127982992003Conservation of the heterochronic regulator Lin-28, its developmental expression and microRNA complementary sites.118
162275732005Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cells.113

Citation

Dessen P

LIN28A (lin-28 homolog A)

Atlas Genet Cytogenet Oncol Haematol. 2010-04-01

Online version: http://atlasgeneticsoncology.org/gene/51415/lin28a