GABARAPL1 (GABA type A receptor associated protein like 1)

2010-05-01  

Identity

HGNC
GABARAPL1
LOCATION
12p13.2
LOCUSID
23710
ALIAS
APG8-LIKE,APG8L,ATG8,ATG8B,ATG8L,GEC1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 23710
MIM: 607420
HGNC: 4068
Ensembl: ENSG00000139112

Variants:

dbSNP: 23710
ClinVar: 23710
TCGA: ENSG00000139112
COSMIC: GABARAPL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139112ENST00000266458Q9H0R8
ENSG00000139112ENST00000266458A0A024RAP5
ENSG00000139112ENST00000421801Q9H0R8
ENSG00000139112ENST00000535576F5GYD9
ENSG00000139112ENST00000537201F5H007
ENSG00000139112ENST00000539170F5GYD9
ENSG00000139112ENST00000539408F5H007
ENSG00000139112ENST00000540424F5H007
ENSG00000139112ENST00000541453F5GX12
ENSG00000139112ENST00000541960G3V1T7
ENSG00000139112ENST00000542722F5H007
ENSG00000139112ENST00000543602Q9H0R8
ENSG00000139112ENST00000544284F5GYD9
ENSG00000139112ENST00000545047F5GX12
ENSG00000139112ENST00000545290A0A0G2JKT8
ENSG00000139112ENST00000545859F5GZY7
ENSG00000139112ENST00000545887Q9H0R8
ENSG00000139112ENST00000545887A0A024RAP5
ENSG00000139112ENST00000546017F5GYD9
ENSG00000139112ENST00000629504F5H007

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
GABAergic synapseKEGGko04727
GABAergic synapseKEGGhsa04727
FoxO signaling pathwayKEGGhsa04068
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
Apelin signaling pathwayKEGGhsa04371
Mitophagy - animalKEGGko04137
Mitophagy - animalKEGGhsa04137
Autophagy - otherKEGGko04136
Autophagy - otherKEGGhsa04136

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370143242023ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience.2
374786272023METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.0
376581352023The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.4
370143242023ATG8-dependent LMX1B-autophagy crosstalk shapes human midbrain dopaminergic neuronal resilience.2
374786272023METTL3 promotes hyperoxia-induced pyroptosis in neonatal bronchopulmonary dysplasia by inhibiting ATG8-mediated autophagy.0
376581352023The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.4
360623072022Loss of GABARAPL1 confers ferroptosis resistance to cancer stem-like cells in hepatocellular carcinoma.5
360623072022Loss of GABARAPL1 confers ferroptosis resistance to cancer stem-like cells in hepatocellular carcinoma.5
339099892021Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.65
339099892021Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.65
326854422020Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.3
333748302020Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.3
326854422020Autophagic Network Analysis of the Dual Effect of Sevoflurane on Neurons Associated with GABARAPL1 and 2.3
333748302020Lack of GABARAP-Type Proteins Is Accompanied by Altered Golgi Morphology and Surfaceome Composition.3
307677002019Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.53

Citation

Dessen P

GABARAPL1 (GABA type A receptor associated protein like 1)

Atlas Genet Cytogenet Oncol Haematol. 2010-05-01

Online version: http://atlasgeneticsoncology.org/gene/51482/gene-fusions-explorer/css/js/lib/zoomerang.js