PLXNA2 (plexin A2)

2010-06-01 Affiliation

Identity

HGNC

PLXNA2

LOCATION

1q32.2

LOCUSID

5362

ALIAS

OCT,PLXN2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5362
MIM: 601054
HGNC: 9100
Ensembl: ENSG00000076356

Variants:

dbSNP: 5362
ClinVar: 5362
TCGA: ENSG00000076356
COSMIC: PLXNA2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000076356	ENST00000367033	O75051

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Axon guidance	KEGG	ko04360
Axon guidance	KEGG	hsa04360
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
Semaphorin interactions	REACTOME	R-HSA-373755
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion	REACTOME	R-HSA-399955
Sema3A PAK dependent Axon repulsion	REACTOME	R-HSA-399954
CRMPs in Sema3A signaling	REACTOME	R-HSA-399956
Other semaphorin interactions	REACTOME	R-HSA-416700

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36658114	2023	Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells.	2
36658114	2023	Plexin-A2 enables the proliferation and the development of tumors from glioblastoma derived cells.	2
33749153	2021	PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder.	4
34327814	2021	PLXNA2 as a candidate gene in patients with intellectual disability.	5
33749153	2021	PLXNA2 and LRRC40 as candidate genes in autism spectrum disorder.	4
34327814	2021	PLXNA2 as a candidate gene in patients with intellectual disability.	5
29091353	2018	Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.	7
29091353	2018	Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development.	7
25518740	2015	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	6
25518740	2015	PlexinA polymorphisms mediate the developmental trajectory of human corpus callosum microstructure.	6
23708657	2014	Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2.	38
25335892	2014	The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.	27
23708657	2014	Identification of novel TMPRSS2:ERG mechanisms in prostate cancer metastasis: involvement of MMP9 and PLXNA2.	38
25335892	2014	The role of the plexin-A2 receptor in Sema3A and Sema3B signal transduction.	27
22095611	2012	PlexinA2 mediates osteoblast differentiation via regulation of Runx2.	7

Citation

Dessen P

PLXNA2 (plexin A2)

Atlas Genet Cytogenet Oncol Haematol. 2010-06-01

Online version: http://atlasgeneticsoncology.org/gene/51531/teaching-explorer/css/template-card.css