FRS3 (fibroblast growth factor receptor substrate 3)

2010-08-01 Affiliation

Identity

HGNC

FRS3

LOCATION

6p21.1

LOCUSID

10817

ALIAS

FRS2-beta,FRS2B,FRS2beta,SNT-2,SNT2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10817
MIM: 607744
HGNC: 16970
Ensembl: ENSG00000137218

Variants:

dbSNP: 10817
ClinVar: 10817
TCGA: ENSG00000137218
COSMIC: FRS3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137218	ENST00000259748	O43559
ENSG00000137218	ENST00000259748	A0A140VJJ7
ENSG00000137218	ENST00000373018	O43559
ENSG00000137218	ENST00000373018	A0A140VJJ7
ENSG00000137218	ENST00000422888	A6PVU0
ENSG00000137218	ENST00000426290	A0A0A0MSM8

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
DAP12 interactions	REACTOME	R-HSA-2172127
DAP12 signaling	REACTOME	R-HSA-2424491
RAF/MAP kinase cascade	REACTOME	R-HSA-5673001
Fc epsilon receptor (FCERI) signaling	REACTOME	R-HSA-2454202
FCERI mediated MAPK activation	REACTOME	R-HSA-2871796
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-2 signaling	REACTOME	R-HSA-451927
Interleukin receptor SHC signaling	REACTOME	R-HSA-912526
Interleukin-3, 5 and GM-CSF signaling	REACTOME	R-HSA-512988
Signal Transduction	REACTOME	R-HSA-162582
Signaling by EGFR	REACTOME	R-HSA-177929
GRB2 events in EGFR signaling	REACTOME	R-HSA-179812
SHC1 events in EGFR signaling	REACTOME	R-HSA-180336
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR1	REACTOME	R-HSA-5654736
Downstream signaling of activated FGFR1	REACTOME	R-HSA-5654687
FRS-mediated FGFR1 signaling	REACTOME	R-HSA-5654693
Signaling by FGFR2	REACTOME	R-HSA-5654738
Downstream signaling of activated FGFR2	REACTOME	R-HSA-5654696
FRS-mediated FGFR2 signaling	REACTOME	R-HSA-5654700
Signaling by FGFR3	REACTOME	R-HSA-5654741
Downstream signaling of activated FGFR3	REACTOME	R-HSA-5654708
FRS-mediated FGFR3 signaling	REACTOME	R-HSA-5654706
Signaling by FGFR4	REACTOME	R-HSA-5654743
Downstream signaling of activated FGFR4	REACTOME	R-HSA-5654716
FRS-mediated FGFR4 signaling	REACTOME	R-HSA-5654712
Signaling by Insulin receptor	REACTOME	R-HSA-74752
Insulin receptor signalling cascade	REACTOME	R-HSA-74751
IRS-mediated signalling	REACTOME	R-HSA-112399
SOS-mediated signalling	REACTOME	R-HSA-112412
Signalling by NGF	REACTOME	R-HSA-166520
NGF signalling via TRKA from the plasma membrane	REACTOME	R-HSA-187037
Signalling to ERKs	REACTOME	R-HSA-187687
Signalling to RAS	REACTOME	R-HSA-167044
Signalling to p38 via RIT and RIN	REACTOME	R-HSA-187706
Prolonged ERK activation events	REACTOME	R-HSA-169893
Frs2-mediated activation	REACTOME	R-HSA-170968
ARMS-mediated activation	REACTOME	R-HSA-170984
Signaling by PDGF	REACTOME	R-HSA-186797
Downstream signal transduction	REACTOME	R-HSA-186763
Signaling by VEGF	REACTOME	R-HSA-194138
VEGFA-VEGFR2 Pathway	REACTOME	R-HSA-4420097
VEGFR2 mediated cell proliferation	REACTOME	R-HSA-5218921
Signaling by SCF-KIT	REACTOME	R-HSA-1433557
MAPK family signaling cascades	REACTOME	R-HSA-5683057
MAPK1/MAPK3 signaling	REACTOME	R-HSA-5684996
Signaling by GPCR	REACTOME	R-HSA-372790
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)	REACTOME	R-HSA-2404192
IGF1R signaling cascade	REACTOME	R-HSA-2428924
IRS-related events triggered by IGF1R	REACTOME	R-HSA-2428928
Signaling by Leptin	REACTOME	R-HSA-2586552
Developmental Biology	REACTOME	R-HSA-1266738
Axon guidance	REACTOME	R-HSA-422475
NCAM signaling for neurite out-growth	REACTOME	R-HSA-375165
RET signaling	REACTOME	R-HSA-8853659

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23279575	2013	Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.	6
23279575	2013	Adaptor protein complex of FRS2β and CIN85/CD2AP provides a novel mechanism for ErbB2/HER2 protein downregulation.	6
20228838	2010	FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.	8
20228838	2010	FRS2beta, a potential prognostic gene for non-small cell lung cancer, encodes a feedback inhibitor of EGF receptor family members by ERK binding.	8
19204726	2009	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	93
19204726	2009	Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.	93
16702953	2006	Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.	12
16702953	2006	Unique role of SNT-2/FRS2beta/FRS3 docking/adaptor protein for negative regulation in EGF receptor tyrosine kinase signaling pathways.	12
15094036	2004	FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.	31
15485655	2004	SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.	4
15094036	2004	FRS2 family docking proteins with overlapping roles in activation of MAP kinase have distinct spatial-temporal patterns of expression of their transcripts.	31
15485655	2004	SNT-2 interacts with ERK2 and negatively regulates ERK2 signaling in response to EGF stimulation.	4
11877385	2002	FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.	7
11877385	2002	FRS2 PTB domain conformation regulates interactions with divergent neurotrophic receptors.	7

Citation

Dessen P

FRS3 (fibroblast growth factor receptor substrate 3)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51593/favicon/css/css/lib/bootstrap.min.css