CREM (cAMP responsive element modulator)

2010-08-01  

Identity

HGNC
CREM
LOCATION
10p11.21
LOCUSID
1390
ALIAS
CREM-2,ICER,hCREM-2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1390
MIM: 123812
HGNC: 2352
Ensembl: ENSG00000095794

Variants:

dbSNP: 1390
ClinVar: 1390
TCGA: ENSG00000095794
COSMIC: CREM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095794ENST00000337656Q03060
ENSG00000095794ENST00000342105Q03060
ENSG00000095794ENST00000344351E9PAR2
ENSG00000095794ENST00000345491Q03060
ENSG00000095794ENST00000348787Q03060
ENSG00000095794ENST00000354759Q03060
ENSG00000095794ENST00000356917Q03060
ENSG00000095794ENST00000361599Q03060
ENSG00000095794ENST00000374721G5E998
ENSG00000095794ENST00000374726Q03060
ENSG00000095794ENST00000374728Q03060
ENSG00000095794ENST00000374734Q03060
ENSG00000095794ENST00000395887Q03060
ENSG00000095794ENST00000427847A0A0A0MSU8
ENSG00000095794ENST00000429130Q03060
ENSG00000095794ENST00000439705Q03060
ENSG00000095794ENST00000460270E9PAR2
ENSG00000095794ENST00000463314Q03060
ENSG00000095794ENST00000463960C9K092
ENSG00000095794ENST00000464475H7C4X0
ENSG00000095794ENST00000468236Q03060
ENSG00000095794ENST00000469949R4GN75
ENSG00000095794ENST00000473940Q03060
ENSG00000095794ENST00000474362E9PB41
ENSG00000095794ENST00000474931Q03060
ENSG00000095794ENST00000479070Q03060
ENSG00000095794ENST00000484283J3KR46
ENSG00000095794ENST00000487132C9IYM9
ENSG00000095794ENST00000487763Q03060
ENSG00000095794ENST00000488328Q03060
ENSG00000095794ENST00000488741Q03060
ENSG00000095794ENST00000489321Q03060
ENSG00000095794ENST00000490460F8WB03
ENSG00000095794ENST00000490511Q03060
ENSG00000095794ENST00000494479C9J2J0
ENSG00000095794ENST00000495301C9J5A7
ENSG00000095794ENST00000495960F8WDF2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
158411822005Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV.82
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
189227882008BDNF selectively regulates GABAA receptor transcription by activation of the JAK/STAT pathway.64
246676402014CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance.53
220256202011cAMP-responsive element modulator (CREM)α protein induces interleukin 17A expression and mediates epigenetic alterations at the interleukin-17A gene locus in patients with systemic lupus erythematosus.47
119883182002The expanding family of CREB/CREM transcription factors that are involved with spermatogenesis.40
203786152010Evaluation of 172 candidate polymorphisms for association with oligozoospermia or azoospermia in a large cohort of men of European descent.40
173324392007Regulation of phosphodiesterase 3 and inducible cAMP early repressor in the heart.33
219766792011cAMP-responsive element modulator (CREM)α protein signaling mediates epigenetic remodeling of the human interleukin-2 gene: implications in systemic lupus erythematosus.31
123703432002Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus.29

Citation

Dessen P

CREM (cAMP responsive element modulator)

Atlas Genet Cytogenet Oncol Haematol. 2010-08-01

Online version: http://atlasgeneticsoncology.org/gene/51595/crem