ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)

2010-10-01 Affiliation

Identity

HGNC

ATP2C2

LOCATION

16q24.1

LOCUSID

9914

ALIAS

SPCA2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 9914
MIM: 613082
HGNC: 29103
Ensembl: ENSG00000064270

Variants:

dbSNP: 9914
ClinVar: 9914
TCGA: ENSG00000064270
COSMIC: ATP2C2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000064270	ENST00000262429	O75185
ENSG00000064270	ENST00000416219	O75185
ENSG00000064270	ENST00000569207	H3BS90

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Transmembrane transport of small molecules	REACTOME	R-HSA-382551
Ion channel transport	REACTOME	R-HSA-983712
Ion transport by P-type ATPases	REACTOME	R-HSA-936837

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35063802	2022	Secretory pathway Ca(2+)-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry.	4
35063802	2022	Secretory pathway Ca(2+)-ATPase SPCA2 regulates mitochondrial respiration and DNA damage response through store-independent calcium entry.	4
33864365	2021	A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.	9
33936088	2021	ATP2C2 Has Potential to Define Tumor Microenvironment in Breast Cancer.	10
33864365	2021	A rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.	9
33936088	2021	ATP2C2 Has Potential to Define Tumor Microenvironment in Breast Cancer.	10
31676354	2020	The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis.	5
31676354	2020	The pancreas-specific form of secretory pathway calcium ATPase 2 regulates multiple pathways involved in calcium homeostasis.	5
30718673	2019	Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership.	20
31076498	2019	A Ca(2+)-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.	21
30718673	2019	Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership.	20
31076498	2019	A Ca(2+)-ATPase Regulates E-cadherin Biogenesis and Epithelial-Mesenchymal Transition in Breast Cancer Cells.	21
30003630	2018	Genome-wide association meta-analysis of age at first cannabis use.	19
30003630	2018	Genome-wide association meta-analysis of age at first cannabis use.	19
27692665	2017	SPCA2 couples Ca(2+) influx via Orai1 to Ca(2+) uptake into the Golgi/secretory pathway.	19

Citation

Dessen P

ATP2C2 (ATPase secretory pathway Ca2+ transporting 2)

Atlas Genet Cytogenet Oncol Haematol. 2010-10-01

Online version: http://atlasgeneticsoncology.org/gene/51703/meetings/css/lib/bootstrap.min.css