NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

2011-01-01  

Identity

HGNC
NPLOC4
LOCATION
17q25.3
LOCUSID
55666
ALIAS
NPL4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55666
MIM: 606590
HGNC: 18261
Ensembl: ENSG00000182446

Variants:

dbSNP: 55666
ClinVar: 55666
TCGA: ENSG00000182446
COSMIC: NPLOC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182446ENST00000331134Q8TAT6
ENSG00000182446ENST00000331134A0A024R8R4
ENSG00000182446ENST00000374747Q8TAT6
ENSG00000182446ENST00000570324I3L4S2
ENSG00000182446ENST00000571714I3L3I1
ENSG00000182446ENST00000572760K7EJN1
ENSG00000182446ENST00000572824I3L0W3
ENSG00000182446ENST00000573212I3L283
ENSG00000182446ENST00000573519I3L281
ENSG00000182446ENST00000573876K7EJN1
ENSG00000182446ENST00000574897I3L4U9
ENSG00000182446ENST00000625705A0A0D9SFI9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
p97-Ufd1-Npl4 complexKEGGhsa_M00400
HRD1/SEL1 ERAD complexKEGGhsa_M00403
HRD1/SEL1 ERAD complexKEGGM00403
p97-Ufd1-Npl4 complexKEGGM00400
DNA RepairREACTOMER-HSA-73894
DNA Damage BypassREACTOMER-HSA-73893
Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateREACTOMER-HSA-110313
Translesion Synthesis by POLHREACTOMER-HSA-110320

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379935842023NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma.1
379935842023NPLOC4 is a potential target and a poor prognostic signature in lung squamous cell carcinoma.1
359206412022Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.11
360875752022Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1.2
359206412022Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase.11
360875752022Structural basis for the interaction between human Npl4 and Npl4-binding motif of human Ufd1.2
334026762021Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.35
334026762021Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.35
326679292020Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma.11
326679292020Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma.11
316239622019Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.40
316239622019Multisystem Proteinopathy Mutations in VCP/p97 Increase NPLOC4·UFD1L Binding and Substrate Processing.40
285122182017Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.96
285122182017Ubiquitin- and ATP-dependent unfoldase activity of P97/VCP•NPLOC4•UFD1L is enhanced by a mutation that causes multisystem proteinopathy.96
261124102015The Transitional Endoplasmic Reticulum ATPase p97 Regulates the Alternative Nuclear Factor NF-κB Signaling via Partial Degradation of the NF-κB Subunit p100.13

Citation

Dessen P

NPLOC4 (NPL4 homolog, ubiquitin recognition factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-01-01

Online version: http://atlasgeneticsoncology.org/gene/51979/deep-insight-explorer/favicon/favicon-32x32.png