DRD3 (dopamine receptor D3)

2011-02-01  

Identity

HGNC
DRD3
LOCATION
3q13.31
LOCUSID
1814
ALIAS
D3DR,ETM1,FET1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 1814
MIM: 126451
HGNC: 3024
Ensembl: ENSG00000151577

Variants:

dbSNP: 1814
ClinVar: 1814
TCGA: ENSG00000151577
COSMIC: DRD3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151577ENST00000295881E9PCM4
ENSG00000151577ENST00000383673P35462
ENSG00000151577ENST00000383673X5D2G4
ENSG00000151577ENST00000460779P35462
ENSG00000151577ENST00000460779X5D2G4
ENSG00000151577ENST00000467632P35462
ENSG00000151577ENST00000467632X5D2G4

Expression (GTEx)

0
1
2
3
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Dopamine receptorsREACTOMER-HSA-390651
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10066duloxetineChemicalClinicalAnnotationassociatedPD22249355
PA153906318Autism Spectrum DisorderDiseaseClinicalAnnotationassociatedPD23856854
PA164742949pramipexoleChemicalClinicalAnnotationassociatedPD19396436
PA444339HallucinationsDiseaseClinicalAnnotationassociatedPD30794329
PA445208PainDiseaseVariantAnnotationnot associatedPD21398039
PA445254Parkinson DiseaseDiseaseClinicalAnnotationassociatedPD19396436, 27779245, 30794329
PA447196Anxiety DisordersDiseaseClinicalAnnotationassociatedPD22249355
PA447198Autistic DisorderDiseaseClinicalAnnotationassociatedPD19997080
PA447199Bipolar DisorderDiseaseClinicalAnnotationassociatedPD19506579
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD18320559, 19506579, 20029384, 21332319
PA447230HIVDiseaseClinicalAnnotationassociatedPD21491142
PA447321Depressive Disorder, MajorDiseaseClinicalAnnotationassociatedPD22926616
PA449061clozapineChemicalClinicalAnnotationassociatedPD20029384, 21332319
PA450213levodopaChemicalClinicalAnnotationassociatedPD27779245, 30794329
PA450403methamphetamineChemicalClinicalAnnotationassociatedPD21491142
PA450464methylphenidateChemicalClinicalAnnotationassociatedPD23856854
PA450688olanzapineChemicalClinicalAnnotationassociatedPD18320559
PA450801paroxetineChemicalClinicalAnnotationassociatedPD22926616
PA451201quetiapineChemicalClinicalAnnotationassociatedPK25025989
PA451257risperidoneChemicalClinicalAnnotationassociatedPD19506579, 19997080
PA452618opioidsChemicalVariantAnnotationnot associatedPD21398039

References

Pubmed IDYearTitleCitations
383636192024DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's Disease: Susceptibility and Protective Effects.0
384310402024Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India.0
389276722024Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients.0
383636192024DRD3 Predicts Cognitive Impairment and Anxiety in Parkinson's Disease: Susceptibility and Protective Effects.0
384310402024Association of dopamine receptor D3 polymorphism with Levodopa-induced Dyskinesia: A study on Parkinson's disease patients from India.0
389276722024Polymorphisms in the Dopaminergic Receptor D3 Gene Correlate with Disease Progression Rate in Relapsing-Remitting Multiple Sclerosis Patients.0
361548482023The genetic influence of the DRD3 rs6280 polymorphism (Ser9Gly) on functional connectivity and gray matter volume of the hippocampus in patients with first-episode, drug-naïve schizophrenia.1
361548482023The genetic influence of the DRD3 rs6280 polymorphism (Ser9Gly) on functional connectivity and gray matter volume of the hippocampus in patients with first-episode, drug-naïve schizophrenia.1
351288302022New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes.2
352852972022HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease.3
358353962022DRD3 Ser9Gly polymorphism and treatment response to antipsychotics in schizophrenia: A meta-analysis.2
359043022022[Association of gene polymorphisms DRD3 rs6280, COMT rs4680 and HTR2A rs7322347 with schizophrenia].0
364569062022Dopamine receptor D3 is related to prognosis in human hepatocellular carcinoma and inhibits tumor growth.1
351288302022New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes.2
352852972022HUMAN STUDY COMT and DRD3 haplotype-associated pain intensity and acute care utilization in adult sickle cell disease.3

Citation

Dessen P

DRD3 (dopamine receptor D3)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52045/deep-insight-explorer/js/lib/css/template-card.css