GPRASP1 (G protein-coupled receptor associated sorting protein 1)

2011-02-01  

Identity

HGNC
GPRASP1
LOCATION
Xq22.1
LOCUSID
9737
ALIAS
GASP,GASP-1,GASP1

Other Information

Locus ID:

NCBI: 9737
MIM: 300417
HGNC: 24834
Ensembl: ENSG00000198932

Variants:

dbSNP: 9737
ClinVar: 9737
TCGA: ENSG00000198932
COSMIC: GPRASP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198932ENST00000361600Q5JY77
ENSG00000198932ENST00000415986Q5JY77
ENSG00000198932ENST00000444152Q5JY77
ENSG00000198932ENST00000537097Q5JY77
ENSG00000198932ENST00000652542Q5JY77

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
121425402002Modulation of postendocytic sorting of G protein-coupled receptors.101
160490992005Dopamine responsiveness is regulated by targeted sorting of D2 receptors.67
219008452012Strength training with blood flow restriction diminishes myostatin gene expression.47
204680642010Association study of 182 candidate genes in anorexia nervosa.30
203947732010Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs).15
192373932009Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort.14
230829962013ARF6 and GASP-1 are post-endocytic sorting proteins selectively involved in the intracellular trafficking of dopamine D₂ receptors mediated by GRK and PKC in transfected cells.8
210305922011Dopamine D(3) receptors are down-regulated following heterologous endocytosis by a specific interaction with G protein-coupled receptor-associated sorting protein-1.7
217183012012The GPCR-associated sorting protein 1 regulates ligand-induced down-regulation of GPR55.4
224838482012G-protein coupled receptor-associated sorting protein 1 (GASP-1), a ubiquitous tumor marker.3

Citation

Dessen P

GPRASP1 (G protein-coupled receptor associated sorting protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-02-01

Online version: http://atlasgeneticsoncology.org/gene/52061/gprasp1