PRCP (prolylcarboxypeptidase)

PRCP (prolylcarboxypeptidase)

2011-03-01 Affiliation

Identity

HGNC

LOCATION

11q14.1

LOCUSID

ALIAS

HUMPCP,PCP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5547
MIM: 176785
HGNC: 9344
Ensembl: ENSG00000137509

Variants:

dbSNP: 5547
ClinVar: 5547
TCGA: ENSG00000137509
COSMIC: PRCP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000137509	ENST00000313010	P42785
ENSG00000137509	ENST00000313010	A0A024R5L0
ENSG00000137509	ENST00000393399	P42785
ENSG00000137509	ENST00000527444	E9PQN3
ENSG00000137509	ENST00000528082	E9PLY4
ENSG00000137509	ENST00000529671	E9PNJ1
ENSG00000137509	ENST00000531128	E9PL85
ENSG00000137509	ENST00000531801	E9PIG4
ENSG00000137509	ENST00000532809	E9PNF7
ENSG00000137509	ENST00000533126	E9PL49
ENSG00000137509	ENST00000534264	E9PR42
ENSG00000137509	ENST00000534396	E9PQB5
ENSG00000137509	ENST00000534631	E9PKN6

Expression (GTEx)

0

5

10

15

20

25

30

35

40

45

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Renin-angiotensin system	KEGG	ko04614
Renin-angiotensin system	KEGG	hsa04614
Protein digestion and absorption	KEGG	ko04974
Protein digestion and absorption	KEGG	hsa04974
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Hemostasis	REACTOME	R-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)	REACTOME	R-HSA-140877
Intrinsic Pathway of Fibrin Clot Formation	REACTOME	R-HSA-140837
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	20079160
PA448561	benazepril	Chemical	ClinicalAnnotation	associated		PD	20079160

References

Pubmed ID	Year	Title	Citations
31837203	2020	Fast oxidation of α-melanocyte-stimulating hormone and derived peptides under laboratory conditions causes irreproducible results-Insights from studies of prolylcarboxypeptidase in human cell types.	1
32448049	2020	Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.	2
33319614	2020	Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.	0
31837203	2020	Fast oxidation of α-melanocyte-stimulating hormone and derived peptides under laboratory conditions causes irreproducible results-Insights from studies of prolylcarboxypeptidase in human cell types.	1
32448049	2020	Genetic association study of prolylcarboxypeptidase polymorphisms with susceptibility to essential hypertension in the Yi minority of China: A case-control study based on an isolated population.	2
33319614	2020	Haplotype-based association study between PRCP gene polymorphisms and essential hypertension in Hani minority group from a remote region of China.	0
28831120	2017	Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.	8
28831120	2017	Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis.	8
27449720	2016	Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme.	9
27449720	2016	Prolyl carboxypeptidase purified from human placenta: its characterization and identification as an apelin-cleaving enzyme.	9
25370794	2015	Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.	5
25370794	2015	Prolyl carboxypeptidase activity decline correlates with severity and short-term outcome in acute ischemic stroke.	5
25324000	2014	Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).	11
25324000	2014	Prolylcarboxypeptidase independently activates plasma prekallikrein (fletcher factor).	11
22679278	2013	Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population.	9

Citation

Dessen P

PRCP (prolylcarboxypeptidase)

Atlas Genet Cytogenet Oncol Haematol. 2011-03-01

Online version: http://atlasgeneticsoncology.org/gene/52116/meetings/deep-insight-explorer/js/web-card-gene.js