MFF (mitochondrial fission factor)

2011-04-01  

Identity

HGNC
LOCATION
2q36.3
LOCUSID
ALIAS
C2orf33,EMPF2,GL004
FUSION GENES

Other Information

Locus ID:

NCBI: 56947
MIM: 614785
HGNC: 24858
Ensembl: ENSG00000168958

Variants:

dbSNP: 56947
ClinVar: 56947
TCGA: ENSG00000168958
COSMIC: MFF

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168958ENST00000304593Q9GZY8
ENSG00000168958ENST00000337110Q9GZY8
ENSG00000168958ENST00000349901Q9GZY8
ENSG00000168958ENST00000353339Q9GZY8
ENSG00000168958ENST00000353339A0A024R491
ENSG00000168958ENST00000354503Q9GZY8
ENSG00000168958ENST00000392059A0A0A0MS29
ENSG00000168958ENST00000409565Q9GZY8
ENSG00000168958ENST00000409616Q9GZY8
ENSG00000168958ENST00000418961C9JU19
ENSG00000168958ENST00000423098C9JI76
ENSG00000168958ENST00000436237C9J846
ENSG00000168958ENST00000443428C9JAF1
ENSG00000168958ENST00000452930C9JHF5
ENSG00000168958ENST00000456345H7C433
ENSG00000168958ENST00000524634E9PPW6
ENSG00000168958ENST00000525195E9PPR7
ENSG00000168958ENST00000530359E9PK16
ENSG00000168958ENST00000531278E9PQX8
ENSG00000168958ENST00000534203E9PKS0

Expression (GTEx)

0
50
100
150
200
250

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
183539692008The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cells.254
239213782013Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission.88
228782332012Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth.47
265785132016Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity.28
225955232012PEX11 proteins attract Mff and human Fis1 to coordinate peroxisomal fission.27
267833682016Disturbed mitochondrial and peroxisomal dynamics due to loss of MFF causes Leigh-like encephalopathy, optic atrophy and peripheral neuropathy.26
259123082015Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1-miR-593-5p-MFF axis.15
282628282017SENP3-mediated deSUMOylation of Drp1 facilitates interaction with Mff to promote cell death.13
232848132012TRAP1 controls mitochondrial fusion/fission balance through Drp1 and Mff expression.12
254310212014miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor.10

Citation

Dessen P

MFF (mitochondrial fission factor)

Atlas Genet Cytogenet Oncol Haematol. 2011-04-01

Online version: http://atlasgeneticsoncology.org/gene/52156/mff