TPT1 (tumor protein, translationally-controlled 1)

2003-02-01  

Identity

HGNC
TPT1
LOCATION
13q14.13
LOCUSID
7178
ALIAS
HRF,TCTP,p02,p23
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7178
MIM: 600763
HGNC: 12022
Ensembl: ENSG00000133112

Variants:

dbSNP: 7178
ClinVar: 7178
TCGA: ENSG00000133112
COSMIC: TPT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133112ENST00000309246Q5W0H4
ENSG00000133112ENST00000379055P13693
ENSG00000133112ENST00000379055A0A024RDY2
ENSG00000133112ENST00000379056P13693
ENSG00000133112ENST00000379056A0A024RDY2
ENSG00000133112ENST00000379060J3KPG2
ENSG00000133112ENST00000527226E9PJF7
ENSG00000133112ENST00000528619H0YCX0
ENSG00000133112ENST00000530245H0YCX0
ENSG00000133112ENST00000530705P13693
ENSG00000133112ENST00000530705A0A0P1J1R0
ENSG00000133112ENST00000616577A0A0B4J2C3

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221576792011Reciprocal repression between P53 and TCTP.76
123995452002Biological models and genes of tumor reversion: cellular reprogramming through tpt1/TCTP and SIAH-1.73
121677142002Plk phosphorylation regulates the microtubule-stabilizing protein TCTP.69
182745532008TCTP protects from apoptotic cell death by antagonizing bax function.61
153194362004TSAP6 facilitates the secretion of translationally controlled tumor protein/histamine-releasing factor via a nonclassical pathway.58
186763702008Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling.56
146239682003Translationally controlled tumor protein acts as a guanine nucleotide dissociation inhibitor on the translation elongation factor eEF1A.52
210811262011Anti-apoptotic protein TCTP controls the stability of the tumor suppressor p53.49
121492732002Physical and functional interaction between myeloid cell leukemia 1 protein (MCL1) and Fortilin. The potential role of MCL1 as a fortilin chaperone.45
224519272012Role of the translationally controlled tumor protein in DNA damage sensing and repair.34

Citation

Dessen P

TPT1 (tumor protein, translationally-controlled 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/522/tpt1