MS4A3 (membrane spanning 4-domains A3)

2011-06-01 Affiliation

Identity

HGNC

MS4A3

LOCATION

11q12.1

LOCUSID

932

ALIAS

CD20L,HTM4

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 932
MIM: 606498
HGNC: 7317
Ensembl: ENSG00000149516

Variants:

dbSNP: 932
ClinVar: 932
TCGA: ENSG00000149516
COSMIC: MS4A3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149516	ENST00000278865	Q96HJ5
ENSG00000149516	ENST00000358152	Q96HJ5
ENSG00000149516	ENST00000395032	Q96HJ5
ENSG00000149516	ENST00000525686	E9PRW8
ENSG00000149516	ENST00000534744	Q96HJ5

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34780648	2022	MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis.	8
34780648	2022	MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis.	8
29274779	2018	Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.	14
29274779	2018	Identification of MS4A3 as a reliable marker for early myeloid differentiation in human hematopoiesis.	14
27579896	2016	A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.	5
27579896	2016	A 7-Gene Signature Depicts the Biochemical Profile of Early Prefibrotic Myelofibrosis.	5
25886616	2015	EVI1 promotes tumor growth via transcriptional repression of MS4A3.	18
25886616	2015	EVI1 promotes tumor growth via transcriptional repression of MS4A3.	18
19818099	2011	Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.	14
19818099	2011	Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.	14
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19
20800603	2010	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	14
20237496	2010	New genetic associations detected in a host response study to hepatitis B vaccine.	37
20677014	2010	An approach based on a genome-wide association study reveals candidate loci for narcolepsy.	19

Citation

Dessen P

MS4A3 (membrane spanning 4-domains A3)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52250/css/favicon/favicon-16x16.png