ACTL6A (actin like 6A)

2011-06-01  

Identity

HGNC
ACTL6A
LOCATION
3q26.33
LOCUSID
86
ALIAS
ACTL6,ARPN-BETA,Arp4,BAF53A,INO80K
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 86
MIM: 604958
HGNC: 24124
Ensembl: ENSG00000136518

Variants:

dbSNP: 86
ClinVar: 86
TCGA: ENSG00000136518
COSMIC: ACTL6A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136518ENST00000392662O96019
ENSG00000136518ENST00000429709O96019
ENSG00000136518ENST00000450518O96019
ENSG00000136518ENST00000487978H7C5S0
ENSG00000136518ENST00000490364C9JQT2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DNA RepairREACTOMER-HSA-73894
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
RMTs methylate histone argininesREACTOMER-HSA-3214858
Nucleotide Excision RepairREACTOMER-HSA-5696398
Global Genome Nucleotide Excision Repair (GG-NER)REACTOMER-HSA-5696399
DNA Damage Recognition in GG-NERREACTOMER-HSA-5696394
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385234072024High expression of ACTL6A leads to poor prognosis of oral squamous cell carcinoma patients through promoting malignant progression.0
385234072024High expression of ACTL6A leads to poor prognosis of oral squamous cell carcinoma patients through promoting malignant progression.0
366310072023Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression.3
367683492023Actin-like Protein 6A Expression Correlates with Cancer Stem Cell-like Features and Poor Prognosis in Ovarian Cancer.4
366310072023Targeting VPS72 inhibits ACTL6A/MYC axis activity in HCC progression.3
367683492023Actin-like Protein 6A Expression Correlates with Cancer Stem Cell-like Features and Poor Prognosis in Ovarian Cancer.4
348982772022DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription.0
351829412022ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.2
365266222022BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation.4
348982772022DNA Damage Triggers the Nuclear Accumulation of RASSF6 Tumor Suppressor Protein via CDK9 and BAF53 To Regulate p53 Target Gene Transcription.0
351829412022ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells.2
365266222022BAF53A drives colorectal cancer development by regulating DUSP5-mediated ERK phosphorylation.4
334082512021ACTL6A promotes repair of cisplatin-induced DNA damage, a new mechanism of platinum resistance in cancer.28
338963142021ACTL6A promotes the growth in non-small cell lung cancer by regulating Hippo/Yap pathway.2
346876032021Increased ACTL6A occupancy within mSWI/SNF chromatin remodelers drives human squamous cell carcinoma.14

Citation

Dessen P

ACTL6A (actin like 6A)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52255/css/favicon/js/_common.js