CRIP2 (cysteine rich protein 2)

2011-08-01 Affiliation

Identity

HGNC

CRIP2

LOCATION

14q32.33

LOCUSID

1397

ALIAS

CRIP,CRP2,ESP1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1397
MIM: 601183
HGNC: 2361
Ensembl: ENSG00000182809

Variants:

dbSNP: 1397
ClinVar: 1397
TCGA: ENSG00000182809
COSMIC: CRIP2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000182809	ENST00000329146	P52943
ENSG00000182809	ENST00000483017	P52943
ENSG00000182809	ENST00000538259	H0YFA4
ENSG00000182809	ENST00000550577	H0YHD8

Expression (GTEx)

100

150

200

250

300

350

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34550632	2021	APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.	13
34773852	2021	Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.	3
34550632	2021	APEX2-based Proximity Labeling of Atox1 Identifies CRIP2 as a Nuclear Copper-binding Protein that Regulates Autophagy Activation.	13
34773852	2021	Prognosis biomarker and potential therapeutic target CRIP2 associated with radiosensitivity in NSCLC cells.	3
29662084	2018	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.	63
29662084	2018	HOXA9 inhibits HIF-1α-mediated glycolysis through interacting with CRIP2 to repress cutaneous squamous cell carcinoma development.	63
26883198	2016	CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.	20
26883198	2016	CRP2, a new invadopodia actin bundling factor critically promotes breast cancer cell invasion and metastasis.	20
22154084	2012	The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.	11
22154084	2012	The LIM domain protein, CRIP2, promotes apoptosis in esophageal squamous cell carcinoma.	11
21540330	2011	Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.	35
21540330	2011	Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kappaB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis.	35
20460109	2010	ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.	2
20460109	2010	ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.	2
12530967	2003	Cysteine-rich LIM-only proteins CRP1 and CRP2 are potent smooth muscle differentiation cofactors.	104

Citation

Dessen P

CRIP2 (cysteine rich protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52310/gene-fusions-explorer/css/deep-insight-explorer