BPIFA1 (BPI fold containing family A member 1)

2011-08-01 Affiliation

Identity

HGNC

BPIFA1

LOCATION

20q11.21

LOCUSID

51297

ALIAS

LUNX,NASG,PLUNC,SPLUNC1,SPURT,bA49G10.5

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51297
MIM: 607412
HGNC: 15749
Ensembl: ENSG00000198183

Variants:

dbSNP: 51297
ClinVar: 51297
TCGA: ENSG00000198183
COSMIC: BPIFA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198183	ENST00000354297	Q9NP55
ENSG00000198183	ENST00000375413	Q9NP55
ENSG00000198183	ENST00000375422	Q9NP55
ENSG00000198183	ENST00000618484	Q9NP55

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Antimicrobial peptides	REACTOME	R-HSA-6803157

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36709941	2023	[Correlation between the mRNA levels of BCRP and LUNX genes and pathological types and stages of patients with non-small cell lung cancer].	0
37223955	2023	Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.	1
38053993	2023	CC16 drives VLA-2-dependent SPLUNC1 expression.	0
36709941	2023	[Correlation between the mRNA levels of BCRP and LUNX genes and pathological types and stages of patients with non-small cell lung cancer].	0
37223955	2023	Lung SPLUNC1 Peptide Derivatives in the Lipid Membrane Headgroup Kill Gram-Negative Planktonic and Biofilm Bacteria.	1
38053993	2023	CC16 drives VLA-2-dependent SPLUNC1 expression.	0
35581745	2022	SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel.	1
36175598	2022	SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.	0
36519134	2022	BPIFA1 is a secreted biomarker of differentiating human airway epithelium.	1
35581745	2022	SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel.	1
36175598	2022	SPLUNC1 regulates LPS-induced progression of nasopharyngeal carcinoma and proliferation of myeloid-derived suppressor cells.	0
36519134	2022	BPIFA1 is a secreted biomarker of differentiating human airway epithelium.	1
31504285	2020	A Rare Mutation in SPLUNC1 Affects Bacterial Adherence and Invasion in Meningococcal Disease.	4
31931521	2020	Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1.	8
32680508	2020	The SPLUNC1-βENaC complex prevents Burkholderia cenocepacia invasion in normal airway epithelia.	3

Citation

Dessen P

BPIFA1 (BPI fold containing family A member 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52329/gene-fusions/favicon/css/lib/dataTables.bootstrap.min.css