GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7)

2011-09-01  

Identity

HGNC
LOCATION
4q34.1
LOCUSID
ALIAS
GALNAC-T7,GalNAcT7
FUSION GENES

Other Information

Locus ID:

NCBI: 51809
MIM: 605005
HGNC: 4129
Ensembl: ENSG00000109586

Variants:

dbSNP: 51809
ClinVar: 51809
TCGA: ENSG00000109586
COSMIC: GALNT7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000109586ENST00000265000Q86SF2
ENSG00000109586ENST00000503213H0YAK0
ENSG00000109586ENST00000505308H0YAH3
ENSG00000109586ENST00000512285E9PBY3

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Mucin type O-glycan biosynthesisKEGGko00512
Mucin type O-glycan biosynthesisKEGGhsa00512
Metabolic pathwaysKEGGhsa01100
O-glycan biosynthesis, mucin type coreKEGGhsa_M00056
O-glycan biosynthesis, mucin type coreKEGGM00056
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
O-linked glycosylationREACTOMER-HSA-5173105
O-linked glycosylation of mucinsREACTOMER-HSA-913709

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
217416002011miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis.131
198445732009MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7.68
223992942012MicroRNA-214 suppresses growth and invasiveness of cervical cancer cells by targeting UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7.67
299701222018Long non-coding RNA-SNHG7 acts as a target of miR-34a to increase GALNT7 level and regulate PI3K/Akt/mTOR pathway in colorectal cancer progression.39
244820442014MicroRNA‑34a/c function as tumor suppressors in Hep‑2 laryngeal carcinoma cells and may reduce GALNT7 expression.26
258097072015Functional elucidation of miR-494 in the tumorigenesis of nasopharyngeal carcinoma.13
276196772016miR-214 inhibits invasion and migration via downregulating GALNT7 in esophageal squamous cell cancer.12
265032142016GALNT7, a target of miR-494, participates in the oncogenesis of nasopharyngeal carcinoma.4
306850862019Structural basis of carbohydrate transfer activity of UDP-GalNAc: Polypeptide N-acetylgalactosaminyltransferase 7.2

Citation

Dessen P

GALNT7 (polypeptide N-acetylgalactosaminyltransferase 7)

Atlas Genet Cytogenet Oncol Haematol. 2011-09-01

Online version: http://atlasgeneticsoncology.org/gene/52386/galnt7