CHMP3 (charged multivesicular body protein 3)

2011-10-01 Affiliation

Identity

HGNC

CHMP3

LOCATION

2p11.2

LOCUSID

51652

ALIAS

CGI-149,NEDF,VPS24

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 51652
MIM: 610052
HGNC: 29865
Ensembl: ENSG00000115561

Variants:

dbSNP: 51652
ClinVar: 51652
TCGA: ENSG00000115561
COSMIC: CHMP3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000115561	ENST00000263856	Q9Y3E7
ENSG00000115561	ENST00000409225	Q9Y3E7
ENSG00000115561	ENST00000409727	Q9Y3E7

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Endocytosis	KEGG	ko04144
Endocytosis	KEGG	hsa04144
ESCRT-III complex	KEGG	hsa_M00412
ESCRT-III complex	KEGG	M00412
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
HIV Infection	REACTOME	R-HSA-162906
HIV Life Cycle	REACTOME	R-HSA-162587
Late Phase of HIV Life Cycle	REACTOME	R-HSA-162599
Budding and maturation of HIV virion	REACTOME	R-HSA-162588
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)	REACTOME	R-HSA-917729
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
18687924	2008	Helical structures of ESCRT-III are disassembled by VPS4.	147
19525971	2009	Structural basis for ESCRT-III protein autoinhibition.	96
17146056	2006	Release of autoinhibition converts ESCRT-III components into potent inhibitors of HIV-1 budding.	95
17711858	2007	The MIT domain of UBPY constitutes a CHMP binding and endosomal localization signal required for efficient epidermal growth factor receptor degradation.	63
16554368	2006	The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.	60
12878588	2003	Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.	57
17686835	2007	Intracellular trafficking and maturation of herpes simplex virus type 1 gB and virus egress require functional biogenesis of multivesicular bodies.	53
17261583	2007	Targeting of AMSH to endosomes is required for epidermal growth factor receptor degradation.	43
21827950	2011	Structural basis for ESCRT-III CHMP3 recruitment of AMSH.	22
16302002	2006	Neuroendocrine-like differentiation of non-small cell lung carcinoma cells: regulation by cAMP and the interaction of mac25/IGFBP-rP1 and 25.1.	11

Citation

Dessen P

CHMP3 (charged multivesicular body protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52434/chmp3-(charged-multivesicular-body-protein-3)