CHMP3 (charged multivesicular body protein 3)

2011-10-01  

Identity

HGNC
CHMP3
LOCATION
2p11.2
LOCUSID
51652
ALIAS
CGI-149,NEDF,VPS24
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51652
MIM: 610052
HGNC: 29865
Ensembl: ENSG00000115561

Variants:

dbSNP: 51652
ClinVar: 51652
TCGA: ENSG00000115561
COSMIC: CHMP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115561ENST00000263856Q9Y3E7
ENSG00000115561ENST00000409225Q9Y3E7
ENSG00000115561ENST00000409727Q9Y3E7

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
ESCRT-III complexKEGGhsa_M00412
ESCRT-III complexKEGGM00412
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
HIV InfectionREACTOMER-HSA-162906
HIV Life CycleREACTOMER-HSA-162587
Late Phase of HIV Life CycleREACTOMER-HSA-162599
Budding and maturation of HIV virionREACTOMER-HSA-162588
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Endosomal Sorting Complex Required For Transport (ESCRT)REACTOMER-HSA-917729
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380381472024CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.1
380381472024CHMP3 promotes the progression of hepatocellular carcinoma by inhibiting caspase‑1‑dependent pyroptosis.1
357101092023A homozygous variant in CHMP3 is associated with complex hereditary spastic paraplegia.1
357101092023A homozygous variant in CHMP3 is associated with complex hereditary spastic paraplegia.1
345975822021RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis.4
345975822021RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis.4
315414682020miR-122-5p promotes aggression and epithelial-mesenchymal transition in triple-negative breast cancer by suppressing charged multivesicular body protein 3 through mitogen-activated protein kinase signaling.26
315414682020miR-122-5p promotes aggression and epithelial-mesenchymal transition in triple-negative breast cancer by suppressing charged multivesicular body protein 3 through mitogen-activated protein kinase signaling.26
244403092014CK2 involvement in ESCRT-III complex phosphorylation.5
244403092014CK2 involvement in ESCRT-III complex phosphorylation.5
218279502011Structural basis for ESCRT-III CHMP3 recruitment of AMSH.26
218279502011Structural basis for ESCRT-III CHMP3 recruitment of AMSH.26
195259712009Structural basis for ESCRT-III protein autoinhibition.123
195259712009Structural basis for ESCRT-III protein autoinhibition.123
186879242008Helical structures of ESCRT-III are disassembled by VPS4.193

Citation

Dessen P

CHMP3 (charged multivesicular body protein 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52434/tumors-explorer/meetings/css/template-nav.css