TUBB4B (tubulin beta 4B class IVb)

2011-10-01  

Identity

HGNC
LOCATION
9q34.3
LOCUSID
ALIAS
Beta2,LCAEOD,TUBB2,TUBB2C
FUSION GENES

Other Information

Locus ID:

NCBI: 10383
MIM: 602660
HGNC: 20771
Ensembl: ENSG00000188229

Variants:

dbSNP: 10383
ClinVar: 10383
TCGA: ENSG00000188229
COSMIC: TUBB4B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188229ENST00000340384P68371

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Pathogenic Escherichia coli infectionKEGGko05130
Gap junctionKEGGhsa04540
Pathogenic Escherichia coli infectionKEGGhsa05130
PhagosomeKEGGko04145
PhagosomeKEGGhsa04145
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Cooperation of Prefoldin and TriC/CCT in actin and tubulin foldingREACTOMER-HSA-389958
Prefoldin mediated transfer of substrate to CCT/TriCREACTOMER-HSA-389957
Formation of tubulin folding intermediates by CCT/TriCREACTOMER-HSA-389960
Post-chaperonin tubulin folding pathwayREACTOMER-HSA-389977
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
AURKA Activation by TPX2REACTOMER-HSA-8854518
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
223604202012Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.18
129270472003Beta class II tubulin predominates in normal and tumor breast tissues.14
208729672010Up-regulation of hnRNP A1, Ezrin, tubulin β-2C and Annexin A1 in sentinel lymph nodes of colorectal cancer.11
183842192008Proteomic comparison of nasopharyngeal cancer cell lines C666-1 and NP69 identifies down-regulation of annexin II and beta2-tubulin for nasopharyngeal carcinoma.10
155487022004Nuclear betaII-tubulin associates with the activated notch receptor to modulate notch signaling.8
199962742009Natural product derivative Bis(4-fluorobenzyl)trisulfide inhibits tumor growth by modification of beta-tubulin at Cys 12 and suppression of microtubule dynamics.7
120375792002Occurrence of nuclear beta(II)-tubulin in cultured cells.6
222646002012Regional differences in expression of β-tubulin isoforms in schizophrenia.6
286489442017Tubulin beta 3 and 4 are involved in the generation of early fibrotic stages.6
291987202017Mutations in TUBB4B Cause a Distinctive Sensorineural Disease.2

Citation

Dessen P

TUBB4B (tubulin beta 4B class IVb)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52442/tubb4b