PIF1 (PIF1 5-to-3 DNA helicase)

2011-10-01  

Identity

HGNC
PIF1
LOCATION
15q22.31
LOCUSID
80119
ALIAS
C15orf20,PIF

Other Information

Locus ID:

NCBI: 80119
MIM: 610953
HGNC: 26220
Ensembl: ENSG00000140451

Variants:

dbSNP: 80119
ClinVar: 80119
TCGA: ENSG00000140451
COSMIC: PIF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140451ENST00000268043Q9H611
ENSG00000140451ENST00000333425Q9H611
ENSG00000140451ENST00000559239Q9H611

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373962012023PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells.0
373962012023PIF1 Promotes Autophagy to Inhibit Chronic Hypoxia Induced Apoptosis of Pulmonary Artery Endothelial Cells.0
351905322022CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.23
351905322022CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.23
330792092021Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.5
334704202021PIF1 helicase promotes break-induced replication in mammalian cells.41
330792092021Dynamic regulation of Pif1 acetylation is crucial to the maintenance of genome stability.5
334704202021PIF1 helicase promotes break-induced replication in mammalian cells.41
321917902020Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.16
325120122020Downregulation of PIF1, a potential new target of MYCN, induces apoptosis and inhibits cell migration in neuroblastoma cells.8
321917902020Mitochondrial genetic variation is enriched in G-quadruplex regions that stall DNA synthesis in vitro.16
325120122020Downregulation of PIF1, a potential new target of MYCN, induces apoptosis and inhibits cell migration in neuroblastoma cells.8
306987962019Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.26
306987962019Structural and functional analysis of the nucleotide and DNA binding activities of the human PIF1 helicase.26
302320072018The Helicase PIF1 Facilitates Resection over Sequences Prone to Forming G4 Structures.22

Citation

Dessen P

PIF1 (PIF1 5-to-3 DNA helicase)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52460/gene-fusions-explorer/css/lib/dataTables.bootstrap.min.css