DCAF7 (DDB1 and CUL4 associated factor 7)

2011-11-01  

Identity

HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
AN11,HAN11,SWAN-1,WDR68
FUSION GENES

Other Information

Locus ID:

NCBI: 10238
MIM: 605973
HGNC: 30915
Ensembl: ENSG00000136485

Variants:

dbSNP: 10238
ClinVar: 10238
TCGA: ENSG00000136485
COSMIC: DCAF7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136485ENST00000415273P61962
ENSG00000136485ENST00000431926P61962
ENSG00000136485ENST00000614556P61962
ENSG00000136485ENST00000615512A0A087WWI6

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Protein foldingREACTOMER-HSA-391251
Chaperonin-mediated protein foldingREACTOMER-HSA-390466
Association of TriC/CCT with target proteins during biosynthesisREACTOMER-HSA-390471

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
209407042010The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions.27
217776252011DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation.21
168873372006HAN11 binds mDia1 and controls GLI1 transcriptional activity.12
253427452014The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation.11
273071982016The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2.9
275732452016Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex.8
304963042018DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B.1
314938722019DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair.1

Citation

Dessen P

DCAF7 (DDB1 and CUL4 associated factor 7)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52484/dcaf7