IFIT1 (interferon induced protein with tetratricopeptide repeats 1)

2011-11-01  

Identity

HGNC
IFIT1
LOCATION
10q23.31
LOCUSID
3434
ALIAS
C56,G10P1,IFI-56,IFI-56K,IFI56,IFIT-1,IFNAI1,ISG56,P56,RNM561
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3434
MIM: 147690
HGNC: 5407
Ensembl: ENSG00000185745

Variants:

dbSNP: 3434
ClinVar: 3434
TCGA: ENSG00000185745
COSMIC: IFIT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185745ENST00000371804P09914
ENSG00000185745ENST00000546318P09914

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Interferon SignalingREACTOMER-HSA-913531
Interferon alpha/beta signalingREACTOMER-HSA-909733
Antiviral mechanism by IFN-stimulated genesREACTOMER-HSA-1169410
ISG15 antiviral mechanismREACTOMER-HSA-1169408

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
216429872011IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.197
233344202013Structural basis for viral 5'-PPP-RNA recognition by human IFIT proteins.95
169736182006Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.88
240981212013Sequestration by IFIT1 impairs translation of 2'O-unmethylated capped RNA.81
190088542008Interferon-inducible protein, P56, inhibits HPV DNA replication by binding to the viral protein E1.79
194168872009ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.76
219766472011ISG56 and IFITM1 proteins inhibit hepatitis C virus replication.76
163854512006A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.69
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
272407342016Evolution-guided functional analyses reveal diverse antiviral specificities encoded by IFIT1 genes in mammals.28

Citation

Dessen P

IFIT1 (interferon induced protein with tetratricopeptide repeats 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52498/ifit1