VTI1A (vesicle transport through interaction with t-SNAREs 1A)

2011-12-01  

Identity

HGNC
VTI1A
LOCATION
10q25.2
LOCUSID
143187
ALIAS
MMDS3,MVti1,VTI1RP2,Vti1-rp2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 143187
MIM: 614316
HGNC: 17792
Ensembl: ENSG00000151532

Variants:

dbSNP: 143187
ClinVar: 143187
TCGA: ENSG00000151532
COSMIC: VTI1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000151532ENST00000393077Q96AJ9

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SNARE interactions in vesicular transportKEGGko04130
SNARE interactions in vesicular transportKEGGhsa04130
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Intra-Golgi and retrograde Golgi-to-ER trafficREACTOMER-HSA-6811442
Retrograde transport at the Trans-Golgi-NetworkREACTOMER-HSA-6811440
Intra-Golgi trafficREACTOMER-HSA-6811438

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
299757812018The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.10
299757812018The VTI1A-TCF4 colon cancer fusion protein is a dominant negative regulator of Wnt signaling and is transcriptionally regulated by intestinal homeodomain factor CDX2.10
283201502017Additional evidence supports association of common genetic variants in VTI1A and ETFA with increased risk of glioma susceptibility.6
283201502017Additional evidence supports association of common genetic variants in VTI1A and ETFA with increased risk of glioma susceptibility.6
257443652015Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung cancer.3
257443652015Single nucleotide polymorphisms in VTI1A gene contribute to the susceptibility of Chinese population to non-small cell lung cancer.3
246089662014High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants.16
251052482014Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.55
246089662014High frequency of fusion transcripts involving TCF7L2 in colorectal cancer: novel fusion partner and splice variants.16
251052482014Trans-ethnic genome-wide association study of colorectal cancer identifies a new susceptibility locus in VTI1A.55
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.17
236776962013VAMP4 is required to maintain the ribbon structure of the Golgi apparatus.17
218921612011Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.181
218921612011Genomic sequencing of colorectal adenocarcinomas identifies a recurrent VTI1A-TCF7L2 fusion.181
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

VTI1A (vesicle transport through interaction with t-SNAREs 1A)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52508/teaching-explorer/cancer-prone-explorer/js/_common.js