GRM3 (glutamate metabotropic receptor 3)

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GRM3 (glutamate metabotropic receptor 3)

2012-01-01 Affiliation

Identity

HGNC

LOCATION

7q21.11

LOCUSID

ALIAS

GLUR3,GPRC1C,MGLUR3,mGlu3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2913
MIM: 601115
HGNC: 4595
Ensembl: ENSG00000198822

Variants:

dbSNP: 2913
ClinVar: 2913
TCGA: ENSG00000198822
COSMIC: GRM3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000198822	ENST00000361669	Q14832
ENSG00000198822	ENST00000361669	A4D1D0
ENSG00000198822	ENST00000421579	C9JIT1
ENSG00000198822	ENST00000439827	Q14832
ENSG00000198822	ENST00000441140	C9JUH9
ENSG00000198822	ENST00000454217	C9J2I2

Expression (GTEx)

0

5

10

15

20

25

30

35

40

45

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Cocaine addiction	KEGG	hsa05030
Cocaine addiction	KEGG	ko05030
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)	REACTOME	R-HSA-420499
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
Phospholipase D signaling pathway	KEGG	ko04072
Phospholipase D signaling pathway	KEGG	hsa04072

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA444460	Heroin Dependence	Disease	ClinicalAnnotation, Literature, MultilinkAnnotation	associated			24498053
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated		PD	19451915, 25096017, 25209194
PA451257	risperidone	Chemical	ClinicalAnnotation	associated		PD	19451915
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated		PD	25096017, 25209194
PA452619	heroin	Chemical	ClinicalAnnotation	associated

References

Pubmed ID	Year	Title	Citations
34290229	2021	Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.	10
34290229	2021	Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma.	10
31925813	2020	Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.	21
32581155	2020	Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.	2
32839935	2020	Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis.	11
31925813	2020	Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis.	21
32581155	2020	Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line.	2
32839935	2020	Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis.	11
28646617	2018	Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.	7
30102917	2018	Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.	15
30488581	2018	Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.	9
28646617	2018	Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.	7
30102917	2018	Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3.	15
30488581	2018	Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival.	9
28114282	2017	The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis.	15

Citation

Dessen P

GRM3 (glutamate metabotropic receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52514/gene-fusions-explorer/js/web-card-gene.js